PMID: 2117251Aug 1, 1990Paper

Antimutagenic effects of mushrooms

Mutation Research
A GrüterF E Würgler

Abstract

A heat-resistant factor in ethanol extracts of the fungus Craterellus cornucopioides completely inhibited the mutagenicity of aflatoxin B1, benzo[a]pyrene, the acridine half mustard ICR-191 and 2-nitrofluorene in a forward-mutation system using Salmonella typhimurium TM677 (screening for 8-azaguanine resistance). There was no inhibitory effect on the mutagenic activity of 4-nitroquinoline-N-oxide, methyl methanesulfonate or N-methyl-N'-nitro-N-nitrosoguanidine. Experiments performed to elucidate the mechanism of the antimutagenic effect showed that neither an alteration of cell viability nor an interference with the excision-repair and the inducible SOS-repair system was involved. The conceivable mechanisms for the antimutagenicity of the ethanol extract include direct chemical interaction with the mutagen and/or inhibition of the activation process in the case of the promutagens. The antimutagenic activity of Craterellus cornucopioides is not unique among mushroom species. The ethanol extracts of 6 other mushrooms showed a similar antimutagenic activity.

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T R SkopekW G Thilly
Dec 1, 1988·Mutation Research·H HayatsuT Negishi
Nov 1, 1984·Mutation Research·T KadaS Kiriyama
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Nov 1, 1980·Cancer Letters·S ArimotoH Hayatsu

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Citations

Dec 1, 1991·Mutation Research·L I VorobjevaN V Vorobjeva
Jun 1, 1992·Mutation Research·G BronzettiA Galli
Feb 19, 1996·Mutation Research·M D WatersS De Flora
Mar 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A GrüterF E Würgler
Aug 3, 2001·Journal of Ethnopharmacology·Y H Shon, K S Nam
Jul 1, 2009·Environmental Toxicology and Pharmacology·Rodrigo Juliano OliveiraMário Sérgio Mantovani
Nov 24, 1999·Journal of Agricultural and Food Chemistry·H S ChungA D Kinghorn

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