PMID: 11909768Mar 23, 2002Paper

Antimutagenic potential of curcumin on chromosomal aberrations in Wistar rats

Mutation Research
Yogeshwer ShuklaPankaj Taneja

Abstract

Curcumin, a yellow pigment commonly used as a spice and food coloring agent is obtained from rhizomes of Curcuma longa and is a major chemopreventive component of turmeric. In the present set of investigations the antimutagenic potential of curcumin has been evaluated using in vivo chromosomal aberration assay in Wistar rats. Cyclophosphamide (CP), a well-known mutagen was given by intraperitoneal (i.p.) injection at the dose of 40 mg/kg body weight (b.w.). Curcumin was given at the dose of 100 and 200 mg/kg b.w. through gastric intubation for seven consecutive days prior to CP treatment. The animals were sacrificed at the sampling time of 24 h after treatment and their bone marrow tissue was analyzed for chromosomal damage and mitotic index. In CP treated animals a significant induction of chromosomal aberration was recorded with decrease in mitotic index. However, in curcumin-supplemented animals, no significant induction in chromosomal damage or change in mitotic index was recorded. In different curcumin-supplemented groups, a dose dependent significant decrease in CP induced clastogenicity was recorded. The incidence of aberrant cells was found to be reduced by both the doses of curcumin when compared to CP treated group. T...Continue Reading

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Citations

Nov 30, 2006·Journal of Applied Genetics·Patricia Urbina-CanoAlfredo Corona-Rivera
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dennis D HeathCheryl L Rock
Jul 5, 2007·Journal of Zhejiang University. Science. B·Irulappan Ragunathan, Natarajan Panneerselvam
Jun 4, 2008·Folia Histochemica Et Cytobiologica·Monika A PapiezAgata Gebarowska
Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal
Aug 11, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A SehgalD K Dhawan
Jun 7, 2003·Nutrition and Cancer·Yogeshwer Shukla, Annu Arora
Oct 19, 2006·Nutrition and Cancer·Reema F TayyemCheryl L Rock
Apr 27, 2007·Vascular Pharmacology·Pei-Han XuZhong-Li Liu
Apr 18, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gražina SlapšytėPetras Rimantas Venskutonis
Jun 22, 2018·ChemMedChem·Srinivasa Reddy BonamVijayapandi Pandy
Feb 16, 2006·Rapid Communications in Mass Spectrometry : RCM·Hongliang JiangDavid R Gang
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Jun 26, 2013·Toxicology and Industrial Health·Abeer A Alm-EldeenHaitham I El-Mekkawy
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Jun 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhe MaZhidong Liu
Nov 19, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yong-Qiang LiuYong-Xian Cheng
May 30, 2021·Bulletin of Experimental Biology and Medicine·N V EreminaA D Durnev
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gábor GirstAttila Hunyadi
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Jan 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Azar Hosseini, Hossein Hosseinzadeh

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