PMID: 7513820May 1, 1994Paper

Antimutagens as cancer chemopreventive agents in the diet

Mutation Research
Lynnette R Ferguson

Abstract

It has been suggested that the use of antimutagens and anticarcinogens in everyday life will be the most effective procedure for preventing human cancer and genetic disease. There are several ways in which mutagenesis can be reduced or prevented. Chemicals which act to interfere with DNA repair or with mutagen metabolism can be effective antimutagens: however such compounds may also increase the probability of mutations by different chemicals or at different sites. In contrast, mutagen scavengers may be less prone to increase mutations by other chemicals. Selected examples illustrate that antimutagenic effects are often specific to certain classes of mutagen and/or certain test systems. Thus, if antimutagens are to have any impact on human disease, it is essential that they are specifically directed against the most common mutagens in daily life. On our current understanding, these are quite diverse in nature, so that combinations of antimutagens will probably be necessary. Two groups of mutagen scavengers (porphyrins and some types of dietary fibre) show some selectivity for large planar and hydrophobic types of carcinogen, which appear to be common in a normal Western diet. Increasing consumption of vitamins C and E, either t...Continue Reading

References

May 1, 1979·Journal of Medicinal Chemistry·L K LamL W Wattenberg
Jun 1, 1992·Mutation Research·H E BrockmanM D Waters
Jun 1, 1992·Mutation Research·S De FloraR Balansky
Jun 1, 1992·Mutation Research·C W BooneG J Kelloff
Jan 8, 1991·Biochemistry·T J McBrideL A Loeb
Nov 1, 1991·Cancer Causes & Control : CCC·K A Steinmetz, J D Potter
Sep 1, 1991·Cancer Causes & Control : CCC·K A Steinmetz, J D Potter
Sep 1, 1991·Mutation Research·B N Ames, L S Gold
Mar 1, 1991·Mutation Research·H U Aeschbacher, R J Turesky
Jan 1, 1990·Environmental and Molecular Mutagenesis·P E Hartman, D M Shankel
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Feb 21, 1990·Journal of the National Cancer Institute·M S MicozziF Khachik
Jan 1, 1989·Free Radical Research Communications·B N Ames
Jan 1, 1986·Bulletin du cancer·J C Jardillier, A Rallet
Dec 1, 1988·Mutation Research·Y Kuroda, T Inoue
Dec 1, 1988·Mutation Research·H HayatsuT Negishi
Jan 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T OhtaT Kada
Oct 1, 1985·Mutation Research·L R FergusonW T Jones
Jan 1, 1983·The Proceedings of the Nutrition Society·K L Simpson
May 1, 1983·Mutation Research·D M Maron, B N Ames
Nov 1, 1993·Mutation Research·M Nagao, T Sugimura
Nov 1, 1993·Mutation Research·P J Harris, L R Ferguson
Jun 5, 1993·Lancet·D H Phillips, S Venitt
Jul 1, 1993·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·G SteineckE Overvik
May 1, 1993·Journal of Pharmaceutical Sciences·Y KashiwadaK H Lee
Sep 1, 1993·Carcinogenesis·M A Morse, G D Stoner

❮ Previous
Next ❯

Citations

Dec 10, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·E A VarandaD C Tavares
Sep 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Ciĝdem EgelNilüfer Aydemir
Mar 5, 2003·Teratogenesis, Carcinogenesis, and Mutagenesis·Yogeshwer ShuklaPankaj Taneja
Mar 1, 2007·Indian Journal of Clinical Biochemistry : IJCB·M MastanP R Parthasarathy
Jan 11, 2012·Chinese Journal of Integrative Medicine·Manjeshwar Shrinath Baliga, Poruthukaran John Kurian
Sep 1, 1995·Mutation Research·H AbdelaliJ F Narbonne
Feb 19, 1996·Mutation Research·L A MitscherD M Shankel
Mar 26, 1996·Mutation Research·P Ryden, J A Robertson
Feb 1, 1995·Mutation Research·C J RompelbergH Verhagen
Jan 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K Abraham
Jan 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K Abraham, U Graf
Mar 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y J Surh, S S Lee
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gökçe TanerNurşen Başaran
Nov 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Rong Tsao, Zeyuan Deng
Dec 4, 2003·Mutation Research·Lynnette R FergusonPhilip J Harris
Dec 4, 2003·Mutation Research·Lúcia Regina Ribeiro, Daisy Maria Favero Salvadori
Sep 28, 1998·Mutation Research·O Sreekumar, A Hosono
Feb 7, 2001·Mutation Research·M A BerhowM J Plewa
Apr 21, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K Abraham
Mar 28, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H VerhagenS Yannai
Dec 23, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I FelzenszwalbA Caldeira-de-Araújo
May 5, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K J BottingL R Ferguson
Jan 24, 2002·Cancer Letters·Yogeshwer Shukla, Pankaj Taneja
Jul 25, 2000·Toxicology Letters·J C de MattosA Caldeira-de-Araújo
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·L R Ferguson
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G R HoffmannP D McMaster
Dec 22, 1998·Mutation Research·K K Vijayalaxmi, R Venu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Cancer
W P Steward, K Brown
Toxicology in Vitro : an International Journal Published in Association with BIBRA
Maryam ZahinFarrukh Aqil
Methods and Findings in Experimental and Clinical Pharmacology
Farrukh Aqil, Iqbal Ahmad
© 2021 Meta ULC. All rights reserved