PMID: 2115617Jun 1, 1990Paper

Antimutagens from Momordica charantia

Mutation Research
A P GuevaraP Finch

Abstract

The antimutagenic principle of the green fruits of Momordica charantia was shown by the micronucleus test to be an intractable mixture of novel acylglucosylsterols. The antimutagens were extracted from the green fruits with ethanol and isolated from the bioactive petroleum ether and carbon tetrachloride extracts by repeated and sequential flash column chromatography. The major component of the mixture is 3-O-[6'-O-palmitoyl-beta-D-glucosyl-stigmasta-5,25(27)-dien and the minor component is the stearyl derivative (Guevara, 1989). At a dosage range in mice of 50-12.5 micrograms extract/g, the mixture reduced by about 80% the number of micronucleated polychromatic erythrocytes induced by the well-known mutagen mitomycin C. Structure-activity correlation studies suggested that the antimutagenic activity may reside in the peculiar lipid-like structure of the acylglucosylsterols. Ingestion of these compounds may result in their absorption in the plasma membrane lipid bilayer which could adversely affect the membrane permeability towards mitomycin C and disrupt the cellular activity of the latter.

References


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Citations

Jun 6, 2007·Biotechnology Letters·Cezary PaczkowskiZdzislaw A Wojciechowski
Aug 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M al-BekairiA H Shah
Dec 12, 1996·Mutation Research·A P GuevaraG Russell
Sep 12, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R EdenharderR Rauscher
Jul 25, 2000·Journal of Ethnopharmacology·P Scartezzini, E Speroni
Apr 21, 1999·Mutation Research·A P GuevaraH Nishino
Mar 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·E WilsonS Walford
Dec 17, 2011·Journal of Ethnopharmacology·Yao MengFubing Shen
Aug 25, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·C GangulyS Das
Aug 16, 2017·BioMed Research International·Rufine FachinanAkadiri Yessoufou

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