PMID: 11916148Mar 28, 2002Paper

Antimycobacterial activity of 3,4-dichlorophenyl-ureas, N,N-diphenyl-ureas and related derivatives

Journal of Enzyme Inhibition
A ScozzafavaC T Supuran

Abstract

Substituted urea derivatives were prepared by reacting 3,4-dichlorophenyl isocyanate with amino acids, dipeptides, histamine or dicyandiamide among others, or from N,N-diphenyl-carbamoyl chloride and amino acids, dipeptides, or histamine. Other derivatives were obtained by reaction of PABA or PAS with arylsulfonyl halides. Some of the new compounds showed appreciable activity as antimycobacterial agents against Mycobacterium tuberculosis H37Rv, producing an inhibition of growth in the range of 80-89%, at a concentration of 6.25 microM. Some derivatives of this series might constitute interesting lead molecules for designing novel types of drugs effective against M. tuberculosis, a re-emerging pathogen both in the developed and under-developed countries.

References

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Aug 1, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A MastrolorenzoC T Supuran
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Jun 27, 2001·Bioorganic & Medicinal Chemistry Letters·A ScozzafavaC T Supuran

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Citations

Jan 20, 2016·International Journal of Molecular Sciences·Malcolm J D'Souza, Dennis N Kevill
Mar 24, 2011·Future Medicinal Chemistry·Prem M S ChauhanMoni Sharma

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