Antimycobacterial Activity of Cinnamaldehyde in a Mycobacterium tuberculosis(H37Ra) Model.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Rafal SawickiGrazyna Ginalska

Abstract

The purpose of the study was to evaluate the antimycobacterial activity and the possible action mode of cinnamon bark essential oil and its main constituent-cinnamaldehyde-against the Mycobacterium tuberculosis ATCC 25177 strain. Cinnamaldehyde was proved to be the main bioactive compound responsible for mycobacterial growth inhibition and bactericidal effects. The antimycobacterial activity of cinnamaldehyde was found to be comparable with that of ethambutol, one of the first-line anti-TB antibiotics. The selectivity index determined using cell culture studies in vitro showed a high biological potential of cinnamaldehyde. In M. tuberculosis cells exposed to cinnamaldehyde the cell membrane stress sensing and envelope preserving system are activated. Overexpression of clgR gene indicates a threat to the stability of the cell membrane and suggests a possible mechanism of action. No synergism was detected with the basic set of antibiotics used in tuberculosis treatment: ethambutol, isoniazid, streptomycin, rifampicin, and ciprofloxacin.

References

Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Juan-Carlos PalominoFrançoise Portaels
May 27, 2005·Antimicrobial Agents and Chemotherapy·Domenico TrombettaGiuseppe Bisignano
Jan 20, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mariam FadliLahcen Hassani
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Oct 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carlos R PolaquiniLuis O Regasini
Dec 31, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rafal SawickiGrazyna Ginalska
Jun 15, 2018·International Journal of Mycobacteriology·Marc Tobias HeinrichsHartmut Derendorf

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Citations

Dec 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shu-Lan QuYi-Fu Yang
Jan 1, 2021·Oxidative Medicine and Cellular Longevity·Marwan AlmoiliqyYuan Lin
Nov 1, 2020·Microbial Pathogenesis·Gabriela M GalliAleksandro S Da Silva
Aug 17, 2021·European Journal of Medicinal Chemistry·Giulia CazzanigaStefania Villa
Sep 18, 2021·Phytotherapy Research : PTR·Fahimeh NourbakhshVahid Soheili

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Methods Mentioned

BETA
PCR

Software Mentioned

GraphPad Prism
GraphPad

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