Antimycobacterial and nitric oxide production inhibitory activities of Ocotea notata from Brazilian restinga

TheScientificWorldJournal
Isabela Francisca Borges CostaMichelle Frazão Muzitano

Abstract

The genus Ocotea (Lauraceae) is distributed mainly in tropical and subtropical regions. Some species of this genus as O. puberula and O. quixos have been described in the literature, showing antibacterial activity. And Ocotea macrophylla showed anti-inflammatory activity with inhibition of COX-1, COX-2, and LOX-5. The purpose of this study was the phytochemical investigation of the plant species Ocotea notata from Restinga Jurubatiba National Park, Macaé, RJ, Brazil, and the search for antimycobacterial fractions and compounds. The crude extract was evaluated for antimycobacterial activity and presented 95.75 ± 2.53% of growth inhibition at 100 µg/mL. Then, it was subjected to a liquid-liquid partition and subsequently was chemically investigated by HPLC, revealing the major presence of flavonoids. In this process the partition fractions hexane, ethyl acetate, and butanol are shown to be promising in the antimycobacterial assay. In addition, ethyl acetate fraction was chromatographed and afforded two flavonoids identified by MS and NMR as afzelin and isoquercitrin. The isolated flavonoids afzelin and isoquercitrin were evaluated for their antimycobacterial activity and for their ability to inhibit NO production by macrophages s...Continue Reading

References

Jun 1, 1997·Planta medica·M F SerraP M de Silva
Jul 16, 1999·Parasitology·S A Da-SilvaB Rossi-Bergmann
Mar 8, 2000·Nature·N MyersJ Kent
Jul 25, 2000·Journal of Ethnopharmacology·S ZschockeJ van Staden
Dec 4, 2001·Planta medica·C L CantrellN H Fischer
Jun 12, 2002·Bioorganic & Medicinal Chemistry·Yuh-Meei LinFa-Ching Chen
Apr 16, 2003·Phytochemical Analysis : PCA·Jenny GreenhamChristine A Williams
Dec 31, 2003·Journal of Ethnopharmacology·G Coelho de SouzaE Elisabetsky
Feb 2, 2006·Planta medica·Michelle F MuzitanoSônia S Costa
May 30, 2006·Phytochemistry·Sorwaporn KoysomboonKan Chantrapromma
May 15, 2007·Fitoterapia·Alain FournetHoracio Heinzen
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cecilia GarlandaAlberto Mantovani
Oct 20, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Joelma Abadia Marciano de PaulaJosé Realino de Paula

❮ Previous
Next ❯

Citations

Apr 17, 2019·Natural Product Research·Rafaella Velloso PereiraIvana Correa Ramos Leal
May 20, 2017·International Journal of Molecular Sciences·Joyce Kelly da SilvaWilliam N Setzer
Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhamad Harith MazlunZunoliza Abdullah

❮ Previous
Next ❯

Methods Mentioned

BETA
FCS
NMR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.