Antimycotic activity of fengycin C biosurfactant and its interaction with phosphatidylcholine model membranes

Colloids and Surfaces. B, Biointerfaces
Lina María González-JaramilloAntonio Ortiz

Abstract

Lipopeptide biosurfactants constitute one of the most promising groups of compounds for the treatment and prevention of fungal diseases in plants. Bacillus subtilis strain EA-CB0015 produces iturin A, fengycin C and surfactin and it has been proven useful for the treatment of black Sigatoka disease in banana plants, an important pathology caused by the fungus Mycosphaerella fijiensis (Morelet). We have found that B. subtilis EA-CB0015 cell free supernatants and purified fractions inhibit M. fijiensis cellular growth. The effect of the purified lipopeptides mentioned above on fungal growth has been also evaluated, observing that iturin A and fengycin C inhibit mycelial growth and ascospore germination, whereas surfactin is not effective. On the hypothesis that the antifungal action of the lipopeptides is associated to their incorporation into biological membranes, ultimately leading to membrane permeabilization, a detailed biophysical study on the interaction of a new isoform of fengycin C with model dipalmitoyphosphatidylcholine (DPPC) membranes has been carried out. Differential scanning calorimetry shows that fengycin C alters the thermotropic phase transitions of DPPC, and is laterally segregated in the fluid bilayer forming...Continue Reading

Citations

Oct 31, 2018·Applied Microbiology and Biotechnology·M Elisa FaitMario C N Saparrat
Nov 7, 2019·Scientific Reports·Anastasiia A ZakharovaOlga S Ostroumova
Jul 8, 2017·Applied Microbiology and Biotechnology·Haobin ZhaoMingliang Jin
Jan 15, 2019·Biochimica Et Biophysica Acta. Biomembranes·Elisabeth MantilTyler J Avis
Sep 9, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Jonathan R CoronelAntonio Ortiz

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.