Antinatriuretic and kaliuretic activities of the reduced derivatives of aldosterone

Endocrinology
C J KenyonD J Morris

Abstract

The mineralocorticoid activities of the two dihydro- and the four tetrahydroisomers of the ring A-reduced derivatives of aldosterone were tested in adrenalectomized male rats. Potency was assessed by three criteria. Overall mineralocorticoid activity is expressed as the ability to reduce the urinary Na+/K+ ratio; antinatriuretic activity is represented by decreases in urinary Na+/creatinine; kaliuretic activity is shown by increases in K+/creatinine. All measurements were made on urine collected in the period 1-3 h postinjection. Measurements of overall activity indicate that the potency of aldosterone is greater than 5 alpha-dihydroaldosterone (DHA) greater than 3 alpha, 5 alpha-tetrahydroaldosterone (THA) greater than 3 alpha, 5 beta-THA greater than 3 beta, 5 alpha-THA greater than 5 beta-DHA greater than 3 beta, 5 beta-THA. Measurements of individual cation effects indicated that reduced derivatives generally, and the 5 alpha-reduced derivatives in particular, have greater antinatriuretic than kaliuretic activity. For example 5 alpha-DHA possesses between 7% and 17% of the antinatriuretic activity of aldosterone but only 0.7-2.7% of the kaliuretic activity. 5 alpha-DHA and 3 alpha, 5 beta-THA at concentrations of 10(-7)M we...Continue Reading

Citations

May 1, 1988·Pflügers Archiv : European journal of physiology·D l'AllemandK Hierholzer
Aug 1, 1983·Journal of Steroid Biochemistry·M McDermottD J Morris
Nov 1, 1984·Journal of Steroid Biochemistry·J WinterV D Bokkenheuser
Jan 1, 1986·Journal of Steroid Biochemistry·D J MorrisA S Brem
May 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·K MatsuzakiT Miyazaki
Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·R B IyerA L Southren
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·D J Morris
Sep 10, 2011·The Journal of Endocrinology·Mark NixonRuth Andrew
May 6, 2011·British Journal of Pharmacology·C YangR Andrew
Jun 1, 1984·Journal of Steroid Biochemistry·M HarnikD J Morris

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