Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra

Journal of Natural Products
George R PettitJ N A Hooper

Abstract

Two new cancer cell growth inhibiting cyclic peroxides, plakorstatins 1 (1) and 2 (2), were isolated from the Indonesian marine sponge Plakortis nigra. The structures of plakorstatins 1 and 2 including relative configuration were elucidated on the basis of mass and 2D NMR spectroscopic interpretations. These are the first plakortides with an epoxy group in the side chain. Plakorstatin 2 was found to differ from plakorstatin 1 only in the configuration of the epoxide group. Both exhibited moderate cancer cell growth inhibition against the murine P388 lymphocytic leukemia cell line with ED(50) values of 1.1 and 0.91 microg/mL, respectively, for peroxides 1 and 2.

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Feb 28, 2003·Organic Letters·Claudio CampagnuoloOrazio Taglialatela-Scafati

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Citations

Feb 3, 2006·Natural Product Reports·John W BluntMichèle R Prinsep
Aug 12, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alejandro M S Mayer, Kirk R Gustafson
Jun 3, 2010·Organic & Biomolecular Chemistry·Stephanie ArztStefan Bräse
Jun 30, 2019·Marine Drugs·Novriyandi HanifJunichi Tanaka
Jul 10, 2007·European Journal of Medicinal Chemistry·Valery M Dembitsky

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