Antineoplastic Agents Targeting Sphingolipid Pathways

Frontiers in Oncology
Alexander KrollMin H Kang

Abstract

Emerging studies in the enigmatic area of bioactive lipids have made many exciting new discoveries in recent years. Once thought to play a strictly structural role in cellular function, it has since been determined that sphingolipids and their metabolites perform a vast variety of cellular functions beyond what was previously believed. Of utmost importance is their role in cellular signaling, for it is now well understood that select sphingolipids serve as bioactive molecules that play critical roles in both cancer cell death and survival, as well as other cellular responses such as chronic inflammation, protection from intestinal pathogens, and intrinsic protection from intestinal contents, each of which are associated with oncogenesis. Importantly, it has been demonstrated time and time again that many different tumors display dysregulation of sphingolipid metabolism, and the exact profile of said dysregulation has been proven to be useful in determining not only the presence of a tumor, but also the susceptibility to various chemotherapeutic drugs, as well as the metastasizing characteristics of the malignancies. Since these discoveries surfaced it has become apparent that the understanding of sphingolipid metabolism and pro...Continue Reading

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Methods Mentioned

BETA
xenograft

Clinical Trials Mentioned

NCT02490930
NCT01762033
NCT03377179
NCT02939807
NCT02229981
NCT02757326
NCT02495415
NCT01719861
NCT01899326
NCT02834611

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