Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model

Nutrition
Peter KubatkaDušan Dobrota

Abstract

There has been considerable interest in both clinical and preclinical research about the role of phytochemicals in the reduction of risk for cancer in humans. The aim of this study was to determine the antineoplastic effects of Chlorella pyrenoidosa in experimental breast cancer in vivo and in vitro. In this experiment, the antineoplastic effects of C. pyrenoidosa in the chemoprevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats were evaluated. Chlorella powder was administered through diet at concentrations of 0.3% and 3%. The experiment was terminated 14 wk after carcinogen administration. At autopsy, mammary tumors were removed and prepared for histopathological and immunohistochemical analysis. In vitro cytotoxicity assay, parameters of apoptosis, and proliferation after chlorella treatment in human breast adenocarcinoma (MCF-7) cells were carried out. Basic parameters of experimental carcinogenesis, mechanism of action (biomarkers of apoptosis, proliferation, and angiogenesis), chosen metabolic variables, and side effects after long-term chlorella treatment in animals were assessed. Chlorella at higher concentration suppressed tumor frequency by 61% (P < 0.02) and lengthened tumor latency by 12...Continue Reading

References

Dec 31, 2003·Nutrition·Alexander Gosslau, Kuang Yu Chen
Mar 2, 2005·Cancer Letters·Eiichi Kotake-NaraAkihiko Nagao
Jun 12, 2008·Phytotherapy Research : PTR·Madamanchi GeethangiliYew-Min Tzeng
Dec 9, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jakob WeissenbergerDonat Kögel
May 24, 2012·Phytotherapy Research : PTR·Yuanxin ZhangWei Shi
Dec 6, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Peter KubatkaPeter Orendáš
Mar 8, 2014·International Journal of Molecular Medicine·Hong JiangHongjun Wang

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Citations

Feb 26, 2016·European Journal of Nutrition·Peter KubatkaDietrich Büsselberg
Apr 5, 2016·Nutrition and Cancer·Peter KubatkaRonald M Przygodzki
Jul 22, 2015·Applied Biochemistry and Biotechnology·Chunli LiaoLinna Shan
May 2, 2015·European Journal of Nutrition·Peter KubatkaDušan Dobrota
Jan 10, 2019·Marine Drugs·Giuseppe ErcolanoAngela Ianaro
Apr 12, 2019·International Journal of Molecular Sciences·Peter KubatkaDietrich Büsselberg
May 20, 2017·Journal of Cellular and Molecular Medicine·Peter KubatkaDietrich Busselberg
Mar 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter KubatkaJan Mojzis
Apr 23, 2020·International Journal of Molecular Medicine·Ping LiuTaek-Jeong Nam
Dec 31, 2020·International Journal of Molecular Sciences·Peter KubatkaJan Mojzis

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