Antineoplastic efficacy of melphalan and N-(2-chloroethyl)-N-nitrosocarbamoyl-omega-lysine, in combination with diazoxide or insulin in autochthonous mammary carcinoma of the Sprague-Dawley rat

Journal of Cancer Research and Clinical Oncology
T KlennerD Schmähl

Abstract

The anticancer activity of melphalan and N-(2-chloroethyl)-N-nitrosocarbamoyl-omega-lysine (CNC-omega-Lys), was compared in the autochthonous, methylnitrosourea-induced mammary carcinoma of the Sprague-Dawley rat. In addition, the influence on the therapeutic efficacy of the combination with diazoxide, causing a mild, reversible diabetes, and with insulin was investigated. The comparison of melphalan and CNC-omega-Lys clearly showed the superiority of melphalan. Both compounds displayed a significant tumour inhibition in their medium and the highest dosages in comparison to the untreated control. The combination with diazoxide resulted for almost all groups in an increased tumour inhibition. Only the lowest dose of CNC-omega-Lys + diazoxide did not reduce the tumour volume significantly versus the control group. The combination with insulin, however, resulted in a loss of tumour inhibition compared to the effect of the cytotoxic drug alone, although in these groups, too, a significant decrease of tumour volumes versus controls could be observed. Mortality was within tolerable limits (less than 20%) through the treatment period for all experimental groups. Median lifespans were increased in all therapy groups, but no additional ...Continue Reading

References

Sep 12, 1979·Biochemical and Biophysical Research Communications·D T Vistica, B Schuette
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P LissoniS Barni
Feb 1, 1990·Onkologie·P UnterburgerH Ehrhart
Jan 1, 1989·European Journal of Cancer & Clinical Oncology·B BetschD Schmähl
Mar 15, 1985·International Journal of Cancer. Journal International Du Cancer·M R BergerP Janetschek
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·W C TangG Eisenbrand
Aug 1, 1970·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J C Heuson, N Legros
Jan 1, 1983·Pharmacology & Therapeutics·D T Vistica
Jul 1, 1983·Medical Hypotheses·S Seely, D F Horrobin
Aug 15, 1983·International Journal of Cancer. Journal International Du Cancer·M BergerD Schmähl
Jan 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F J Ballard, J M Gunn

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Citations

May 15, 1992·Cancer·S SchraubC Vrousos

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