PMID: 2105580Jan 1, 1990Paper

Antineutrophil antibodies in vasculitis

Advances in Nephrology From the Necker Hospital
C O Savage, C M Lockwood

Abstract

Antineutrophil cytoplasm antibodies appear highly specific to the primary systemic vasculitides, in particular to Wegener's granulomatosis and microscopic polyarteritis. Their occurrence in idiopathic crescentic rapidly progressive glomerulonephritis supports the view that this disorder may be regarded as a renal limited form of microscopic polyarteritis. The high sensitivity and specificity of ANCA detected using indirect immunofluorescence or solid phase techniques aids the primary diagnosis of these disorders; the measurement of ANCA may also be of value in long-term monitoring since disease relapse appears to occur only when ANCA are present, and it may therefore be inadvisable to withdraw immunosuppressive treatment until ANCA have been undetectable for extended periods of observation. However, the continued presence or reappearance of ANCA following initial induction of disease remission is not necessarily in concord with overt disease activity, although ANCA has been present in all patients in whom disease relapse has occurred. To understand further the role and relationship of ANCA to the vasculitic diseases requires elucidation of the autoantigen, and in this regard various neutrophil enzymes would appear to be likely ...Continue Reading

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
S Aotsuka
Baillière's Clinical Rheumatology
C G Kallenberg
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
D J PudifinK B Parag
© 2021 Meta ULC. All rights reserved