Antineutrophil cytoplasmic autoantibody-associated rapidly progressive glomerulonephritis in a patient with primary biliary cirrhosis

The American Journal of the Medical Sciences
Tsukasa NakamuraHikaru Koide

Abstract

A 72-year-old woman with primary biliary cirrhosis (PBC) and antineutrophil cytoplasmic autoantibody (ANCA)-associated rapidly progressive glomerulonephritis is described. She had a 6-year history of PBC diagnosed histologically, with a positive test finding for antimitochondrial antibodies and elevated biliary enzyme activity. The myeloperoxidase-ANCA test result was negative. The patient was treated with ursodeoxycholic acid (600 mg/day) and had been stable for 6 years. She was admitted to our hospital because of general fatigue, exertional dyspnea, and peripheral edema. Her serum level of creatinine was increased (4.4 mg/dL), and her hemoglobin concentration was reduced (8.0 g/dL). The patient was diagnosed as having rapidly progressive glomerulonephritis. Test results for serum antinuclear antibody and myeloperoxidase-ANCA were positive. The diagnosis by renal biopsy was necrotizing crescentic glomerulonephritis. Prednisolone followed by methylprednisolone pulse therapy and cyclophosphamide were administered. The patient underwent plasma exchange twice weekly for 4 weeks. After 4 weeks, her serum creatinine level fell to 1.8 mg/dL, and she recovered renal function without hemodialysis. After 24 weeks, her renal function (se...Continue Reading

References

Nov 1, 1996·European Journal of Gastroenterology & Hepatology·F SeiboldM Scheurlen
Mar 24, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D VlassopoulosV Hadjiconstantinou
Aug 26, 1998·Internal Medicine·T KomatsuT Oyaizu
May 5, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·N YoriokaM Yamakido
Sep 30, 1999·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·T AkimotoY Asano
May 4, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C M HullJ D Knostman
Oct 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B A Cohen, W F Clark
Jul 27, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·G Gaskin, C D Pusey
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ingeborg ZäunerJoachim Böhler
Apr 12, 2002·Journal of Hepatology·Uwe RitzelGiuliano Ramadori
Apr 23, 2002·Journal of Gastroenterology and Hepatology·Manuela NeumanKeith Lindor
May 25, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Wanda F ReynoldsJan W Cohen Tervaert
Feb 11, 2004·Clinical & Developmental Immunology·Saif Abu-MouchM Eric Gershwin
Feb 11, 2004·Clinical & Developmental Immunology·Patrick S C LeungM Eric Gershwin
Feb 21, 2004·Lancet·Pietro InvernizziMauro Podda
Mar 17, 2004·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Giovanni M FrascàSergio Stefoni

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Citations

Sep 24, 2009·Rheumatology International·Kei OhnumaChikao Morimoto
Nov 21, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Elena Ruiz-FerrerasJosé Matías Tabernero-Romo
Dec 14, 2016·World Journal of Hepatology·Ying-Qiu Huang

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