Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration

European Journal of Pharmacology
Anthony Poon, J Sawynok

Abstract

Spinal administration of adenosine analogs and an adenosine kinase inhibitor produces antinociception in thermal threshold tests. In the present study, we determined the effects of N6-cyclohexyladenosine (adenosine A1 receptor selective), 2-[p-(2-carboxyethyl)phenylethylamino]-5'-N-ethyl-carboxamidoadeno sine (CGS-21680) (adenosine A2A receptor selective), and 5'-N-ethylcarboxamidoadenosine (NECA) (non-selective), on formalin induced nociceptive responses (flinching/lifting and licking/biting) using two concentrations of formalin (2% and 5%). We also examined the antinociceptive effects of 5'-amino-5'-deoxyadenosine, an adenosine kinase inhibitor, and deoxycoformycin, an adenosine deaminase inhibitor, under these conditions. Adenosine A1 receptor agonists, but not the A2A selective agent, produced significant antinociception, as did 5'-amino-5'-deoxyadenosine, but not deoxycoformycin. The extent of antinociception produced was greater with the lower stimulus intensity. The effects of NECA and 5'-amino-5'-deoxyadenosine were inhibited by caffeine, indicating the involvement of cell surface adenosine receptors in their actions. We conclude (a) that the adenosine A1, but not the A2A, receptor is involved in spinally mediated antin...Continue Reading

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Citations

May 20, 1999·Molecular Reproduction and Development·S M Downs
Mar 7, 1996·European Journal of Pharmacology·J Sawynok, A Reid
Jun 27, 1996·European Journal of Pharmacology·K GolembiowskaJ Sawynok
Sep 19, 1996·European Journal of Pharmacology·G J Keil, G E DeLander
Jun 3, 2004·Neuroscience and Biobehavioral Reviews·Patrick Raboisson, Radhouane Dallel
Jul 3, 1998·European Journal of Pharmacology·J Sawynok
Dec 29, 1998·European Journal of Pharmacology·G B Kaplan, T S Coyle
May 7, 2002·Life Sciences·Jorge E Torres-LópezVinicio Granados-Soto
May 26, 1999·Pharmacology, Biochemistry, and Behavior·E A KowalukM F Jarvis
Nov 7, 2000·Acta Anaesthesiologica Scandinavica·V Dahl, J C Raeder
Feb 6, 2004·Clinical and Experimental Pharmacology & Physiology·Sumiyoshi KiguchiMasami Kojima
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Yu-Ming ChiShinobu Sakurada
Jan 24, 2007·Veterinary Anaesthesia and Analgesia·Makoto AsakawaLysa P Posner
Jul 5, 2005·Expert Opinion on Investigational Drugs·E A Kowaluk
Nov 4, 2000·Expert Opinion on Investigational Drugs·E A Kowaluk, M F Jarvis
Aug 17, 2001·Anesthesiology·H L PanJ C Eisenach
Jan 3, 2009·Journal of Korean Medical Science·Myung Ha YoonCui Jin Hua
Aug 17, 2004·Journal of Korean Medical Science·Myung Ha YoonHong Beom Bae
Oct 26, 2005·Anesthesia and Analgesia·Myung Ha YoonJeong Il Choi
Apr 18, 2013·Pharmacological Reviews·Detlev Boison
Sep 15, 1999·Anesthesiology·A ChiariJ C Eisenach

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