Antinociception induced by epidural motor cortex stimulation in naive conscious rats is mediated by the opioid system

Behavioural Brain Research
Erich T FonoffRenata Giorgi

Abstract

Epidural motor cortex stimulation (MCS) has been used for treating patients with neuropathic pain resistant to other therapeutic approaches. Experimental evidence suggests that the motor cortex is also involved in the modulation of normal nociceptive response, but the underlying mechanisms of pain control have not been clarified yet. The aim of this study was to investigate the effects of epidural electrical MCS on the nociceptive threshold of naive rats. Electrodes were placed on epidural motor cortex, over the hind paw area, according to the functional mapping accomplished in this study. Nociceptive threshold and general activity were evaluated under 15-min electrical stimulating sessions. When rats were evaluated by the paw pressure test, MCS induced selective antinociception in the paw contralateral to the stimulated cortex, but no changes were noticed in the ipsilateral paw. When the nociceptive test was repeated 15 min after cessation of electrical stimulation, the nociceptive threshold returned to basal levels. On the other hand, no changes in the nociceptive threshold were observed in rats evaluated by the tail-flick test. Additionally, no behavioral or motor impairment were noticed in the course of stimulation session ...Continue Reading

References

Nov 1, 1978·Annals of Neurology·A I Basbaum, H L Fields
Jan 1, 1987·Acta Anaesthesiologica Scandinavica. Supplementum·C Benedetti
Jan 1, 1988·Experimental Brain Research·R J MilneS C Gandevia
Jul 29, 1985·Brain Research·S G Hardy
Nov 19, 1965·Science·R Melzack, P D Wall
Jul 7, 1980·Brain Research·M A Biedenbach, J L Devito
Dec 1, 1995·Journal of Neurosurgery·S Canavero, V Bonicalzi
Aug 1, 1995·British Journal of Anaesthesia·J A Stamford
Mar 1, 1993·Journal of Neurosurgery·T TsubokawaS Koyama
Aug 27, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Kerry McAlonan, Verity J Brown
Oct 16, 2002·Stereotactic and Functional Neurosurgery·Y KatayamaC Fukaya
Mar 7, 1957·Acta Physiologica Scandinavica·U F LINDBLOM, J O OTTOSSON
Dec 25, 2004·Cellular and Molecular Life Sciences : CMLS·P T OharaL Jasmin
Mar 18, 2005·Comptes rendus biologies·Alim-Louis BenabidFrançois Berger
Dec 14, 2006·The Medical Clinics of North America·Todd W Vanderah
Apr 17, 2007·The European Journal of Neuroscience·D Le PeraM Valeriani
Oct 18, 2007·Experimental Brain Research·Simon VaculínRichard Rokyta

❮ Previous
Next ❯

Citations

Oct 15, 2009·Experimental Brain Research·Hanna Viisanen, Antti Pertovaara
Jun 2, 2011·Case Reports in Medicine·Andrea Di Rollo, Stefano Pallanti
Dec 12, 2012·Surgical Neurology International·Guillermo A Monsalve
Jan 23, 2013·Brain Research·Ruei-Jen ChiouChung-Chih Kuo
Jan 22, 2013·The Journal of Pain : Official Journal of the American Pain Society·Myeounghoon ChaRadi Masri
Aug 31, 2011·Behavioural Brain Research·Sandra Kobaiter-MaarrawiMichel Magnin
Sep 30, 2010·Peptides·Richard J Bodnar
Jun 15, 2010·Brain Research·Gerardo Rojas-PiloniJavier Rodríguez-Jiménez
Sep 13, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Kyou Sik MinSung June Kim
Oct 17, 2015·European Journal of Pain : EJP·X MoissetD Bouhassira
Dec 2, 2014·Archives of Physical Medicine and Rehabilitation·Ricardo GalhardoniDaniel Ciampi de Andrade
Dec 15, 2010·Pain·Daniel Ciampi de AndradeDidier Bouhassira
Aug 12, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G CruccuN Attal
Apr 14, 2016·PloS One·Luiz Fabio DimovRosana Lima Pagano
Apr 16, 2011·Stereotactic and Functional Neurosurgery·Erich Talamoni FonoffManoel Jacobsen Teixeira
Sep 8, 2010·European Journal of Pain : EJP·Rosana L PaganoLuiz R Britto
Jan 6, 2019·Journal of Neurosurgery·Emerson Magno de AndradeErich T Fonoff
Mar 27, 2019·Behavioral and Brain Functions : BBF·Patrícia Sanae Souza LopesRosana Lima Pagano
Jun 1, 2017·Scientific Reports·Brian W LeBlancCarl Y Saab
Sep 19, 2017·Molecular Neurobiology·Damien P Kuffler
Aug 23, 2017·British Journal of Sports Medicine·Brian HainlineLars Engebretsen
Jan 22, 2021·Current Physical Medicine and Rehabilitation Reports·Timothy J MeekerJoel D Greenspan
Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Xiaoyun LiWeiwei Peng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.