PMID: 9175584Feb 1, 1997Paper

Antinociception induced by SM 32 depends on a central cholinergic mechanism

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
C GhelardiniA Bartolini

Abstract

The antinociceptive effect of SM 32 was examined in mice by using the hot-plate (10-40 mg kg(-1) i.p; 3-30 microg per mouse i.c.v.) and abdominal constriction (10-30 mg kg(-1) i.p) tests. In the antinociceptive dose-range, SM 32 did not impair mouse spontaneous motility and motor coordination evaluated respectively by the Animex and rota-rod tests. The increase in the pain threshold produced by SM 32 was prevented by dicyclomine, pirenzepine and hemicholinium-3 but not by naloxone and CGP 35348. In vitro experiments showed that the SM 32 amplified electrically- and nicotine-evoked guinea-pig ileum contractions. On the basis of the above data, it can be postulated that SM 32 exerts its antinociceptive effect through a potentiation of central cholinergic transmission.

References

Feb 1, 1977·Japanese Journal of Pharmacology·H KuribaraS Tadokoro
Jan 1, 1992·British Journal of Pharmacology·A BartoliniA Giotti
Sep 1, 1990·British Journal of Pharmacology·C GhelardiniA Bartolini
Mar 1, 1957·British Journal of Pharmacology and Chemotherapy·T J HALEY, W G MCCORMICK

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