Antinociceptive activity and mechanism of action of detomidine

Journal of Veterinary Pharmacology and Therapeutics
R Virtanen

Abstract

The antinociceptive activity and mechanism of action of detomidine, a novel sedative-analgesic, were studied in mice and rats. Xylazine and morphine were included in the studies for comparison. In both acetic acid-induced writhing test in mice, and in tail flick test in rats, detomidine had potent, dose-dependent antinociceptive effects with ED50 values of 0.06 and 0.2 mg/kg i.p., respectively. Both xylazine and morphine were clearly less potent than detomidine in these tests. The antinociceptive effect of detomidine was only inhibited by alpha-2 antagonists (idazoxan, rauwolscine), which suggests that this action is mediated through stimulation of alpha-2 adrenoceptors. The significance of these findings for the use of detomidine in veterinary medicine is discussed.

Citations

Jun 22, 1988·European Journal of Pharmacology·S G KamerlingC A Bagwell
Jan 1, 1993·Research in Veterinary Science·J P ChambersA E Goodship
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·Alexander Valverde
Aug 6, 2008·Medicinal Research Reviews·Maria Paola GiovannoniVittorio Dal Piaz
Sep 1, 1988·Journal of Autonomic Pharmacology·S G KamerlingC A Bagwell
Apr 1, 1991·Zentralblatt für Veterinärmedizin. Reihe A·M RaekallioM Scheinin

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