Antinociceptive Activity of Phloroglucinol Derivatives Isolated from Southern Brazilian Hypericum Species

Chemistry & Biodiversity
Henrique BridiGilsane Lino von Poser

Abstract

The south Brazilian Hypericum species have revealed the presence of a series of biologically active phloroglucinol derivatives. In this study, a mixture of japonicine A and an isomer with an unreported structure, named japonicine E, was isolated from the roots of H. polyanthemum. Additionally, uliginosin A from H. myrianthum, isouliginosin B from H. polyanthemum, hyperbrasilol B and isohyperbrasilol B from H. caprifoliatum and cariphenone A from H. carinatum were also isolated. The structures were elucidated using 1D- and 2D-NMR experiments and by comparison with previously reported data. The compounds japonicines A/E, uliginosin A, isouliginosin B, hyperbrasilol B and cariphenone A exhibited antinociceptive activity in the mice hot-plate test and did not induce motor impairment in the rotarod apparatus.

References

Nov 1, 1995·Phytochemistry·L RochaK Hostettmann
Feb 22, 2000·Lancet·D Wheatley
Jul 17, 2001·Phytochemistry·A B FerrazG L Lino von Poser
Jun 1, 1981·Planta medica·J-D KantV Wray
Jun 1, 1981·Planta medica·O GasićM Popović
May 21, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander Panossian

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Citations

Sep 27, 2019·Mini Reviews in Medicinal Chemistry·Mariangela MarrelliFilomena Conforti

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