Antinociceptive activity of the essential oil from Artemisia ludoviciana

Journal of Ethnopharmacology
Gerardo D Anaya-EugenioRachel Mata

Abstract

Aerial parts of Artemisia ludoviciana are widely used in Mexico for treating gastrointestinal disorders, painful complaints and diabetes. To establish the preclinical efficacy as antinociceptive agent of the essential oil (EO) from the aerial parts of A. ludoviciana using well-known animal models. Acute antinociceptive effect of EO (1, 10, 31.6, 100, and 316mg/kg, i.p.) was evaluated using the hot plate and paw formalin models in mice. The motor effects were assessed with the rota-rod and open field assays. The volatile components obtained by headspace solid phase microextraction (HS-SPME) and hydrodistillation were determined using gas chromatography coupled with mass spectrometry (GC-MS) analysis. EO decreased first and second phases of formalin test; in the first stage, the better effect was obtained with the treatment of 316mg/kg but in the second phase, time licking was attenuated at the doses of 31.6, 100 and 316mg/kg. The effectiveness of EO (ED50=25.9mg/kg) for attenuating neurogenic pain was corroborated using the hot plate test. The antinociceptive action of EO was blocked by naloxone suggesting that its mode of action involved an opioid mechanism. Furthermore, EO (316mg/kg) did not affect animal motor and coordinatio...Continue Reading

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Citations

Apr 24, 2016·Journal of Ethnopharmacology·Adolfo Andrade-Cetto, Michael Heinrich
May 31, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raimundo Gonçalves de Oliveira JúniorJackson Roberto Guedes da Silva Almeida
Feb 29, 2020·International Journal of Molecular Sciences·Sachiko Koyama, Thomas Heinbockel
May 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ze-Jun Wang, Thomas Heinbockel
Dec 6, 2019·Peptides·Richard J Bodnar
Mar 19, 2021·Frontiers in Pharmacology·Damiana ScuteriMaria Tiziana Corasaniti
Apr 11, 2021·Chemistry and Physics of Lipids·Guilherme Nuñez JaroqueLuciano Caseli
Jun 16, 2021·Journal of Ethnopharmacology·Matthias S GeckMarco Leonti
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan Francisco Palacios-EspinosaIrma Romero
Jun 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Andreza Fabiana BegnamiVera L Garcia Rehder

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