Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models.

Journal of Natural Medicines
Mohd Roslan SulaimanM T Hidayat

Abstract

This study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of Kaempferia galanga leaves using various animal models. The extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in distilled water (dH(2)O) for 72 h and administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot-plate and formalin tests, with activity observed in all tests occurring in a dose-dependent manner. Furthermore, the antinociceptive activity of K. galanga extract was significantly (P < 0.05) reversed when prechallenged with 10 mg/kg naloxone. The extract also produced a significantly (P < 0.05) dose-dependent anti-inflammatory activity when assessed using the carrageenan-induced paw-edema test. In conclusion, this study demonstrated that K. galanga leaves possessed antinociceptive and anti-inflammatory activities and thus supports the Malay's traditional uses of the plant for treatments of mouth ulcer, headache, sore throat, etc.

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Citations

Jun 28, 2014·BioMed Research International·Shamala SalvamaniMohd Yunus Shukor
Sep 30, 2010·Phytotherapy Research : PTR·Chantana MekseepralardJenny M Wilkinson
Apr 24, 2013·Phytotherapy Research : PTR·Hyun-Ju KoDong-Seok Kim
May 28, 2015·BMC Complementary and Alternative Medicine·Mohammad Shawkat AliMahmuda Nasrin
Oct 11, 2016·Journal of Ethnopharmacology·Puralae Channabasavaiah JagadishGopalan Kutty Nampurath
Jul 2, 2010·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Mohammed RahmatullahMd Ariful Haque Mollik
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Mar 23, 2021·International Journal of Food Science·Novi SafrianiEndang Prangdimurti
Oct 2, 2009·Peptides·Richard J Bodnar

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