Antinociceptive and anti-inflammatory activities of Philodendron bipinnatifidum Schott ex Endl (Araceae)

Journal of Ethnopharmacology
Jaqueline ScapinelloDébora de Oliveira

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Popular medicine use stems of Philodendron bipinnatifidum (Araceae) in inflammation cases, such as in erysipelas, as well as orchitis and rheumatism treatment. The present study, conducted for the first time in literature, investigate the antinociceptive and anti-inflammatory activities of P. bipinnatifidum stems ethyl acetate extract (EPB). GC/MS and HPLC analysis were performed for EPB extract. We used EPB at 250, 375 and 500 mg/kg (oral route, p.o.) in male Swiss mice. The antinociceptive activity of the plant extract assessed by acetic acid induced writhing and formalin tests. To investigate the possible participation of opioid system in EPB-mediated effects, we previously administered naloxone to the mice. Anti-inflammatory activity was evaluated using carrageenan-induced paw oedema. The open-field test aimed to investigate the possible EPB effects on the locomotor and exploratory activities. To assess the protective role of EPB on carrageenan-induced oxidative stress, the levels of NPSH, TBARS, as well as SOD and CAT activities were evaluated in blood and paw tissue. The acute toxicity of the EPB was investigated using OECD 423 guideline. The EPB chemical analysis by GC/MS and HPLC revealed...Continue Reading

Citations

Jul 23, 2020·Brazilian Journal of Biology = Revista Brasleira De Biologia·J Lazzarotto-FigueiróJ Dal Magro
Sep 19, 2020·Journal of Inflammation Research·Gebretsadkan Hintsa TekuluEphrem Mebrahtu Araya
Nov 29, 2020·Journal of Ethnopharmacology·Hesham R El-SeediRob Verpoorte
Mar 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Fernanda PetryLiz G Müller
Oct 18, 2021·Behavioural Pharmacology·Letícia Vidor MorganLiz Girardi Müller

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