Antinociceptive and anti-inflammatory effects of Dorstenia barteri (Moraceae) leaf and twig extracts in mice

Journal of Ethnopharmacology
N O A OmisoreJ A Ojewole

Abstract

The present study was undertaken to investigate the antinociceptive and anti-inflammatory activities of the leaf and twig extracts of Dorstenia barteri (Moraceae) in mice. Both the leaf and twig extracts of Dorstenia barteri at 50, 100 and 200 mg/kg showed significant (P < 0.05-0.01) antinociceptive activities in chemical-, mechanical- and thermal-induced pain test models. Intraperitoneal administration of the plant extracts at 50, 100 and 200 mg/kg significantly (P < 0.05-0.01) inhibited carrageenin-induced acute inflammation in oedema paw weight, pulmonary oedema and number of pleural leucocytes in a dose-dependent way. The twig extract was found to be more active than the leaf extract in all the experimental models used. The inhibitory effects of the plant extracts were comparable to those of the reference drugs acetylsalicyclic acid (ASA) and phenylbutazone (PBZ) at 100 mg/kg i.p. The significant reduction in acetic acid-induced abdominal contractions, the decrease in oedema paw weight as well as in the number of leucocytes in the pleural cavity exudates, and the significant increase in the reaction time and pain threshold of mice observed in this study suggest that Dorstenia barteri extracts possess both anti-inflammatory ...Continue Reading

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Citations

Oct 18, 2011·Natural Product Research·Herve Martial P PoumaleYoshihito Shiono
Apr 13, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Catharina E FingoloMaria Auxiliadora C Kaplan
Mar 1, 2011·Journal of Ethnopharmacology·Ismail O IsholaOlufunmilayo O Adeyemi
Mar 17, 2009·Phytotherapy Research : PTR·Olumayokun A OlajideColin W Wright
May 12, 2015·Journal of Medicinal Food·Abidemi James AkindeleBlessing Amarachi Usuwah
Jun 7, 2015·Archives of Pharmacal Research·Jean Paul DzoyemJacobus N Eloff
Mar 6, 2012·Journal of Ethnopharmacology·Bolanle IbrahimMaryna Van de Venter
Jul 12, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N O A OmisoreJ Watchueng
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Mahmoud BahmaniMahmoud Rafieian-Kopaei
Jan 1, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Mary GulumianVanessa Steenkamp

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