Antinociceptive and anti-inflammatory effects of Caryocar coriaceum Wittm fruit pulp fixed ethyl acetate extract on zymosan-induced arthritis in rats

Journal of Ethnopharmacology
Francisco Fábio Bezerra de OliveiraMariana Lima Vale

Abstract

The ethyl acetate extract from the fruit pulp of Caryocar coriaceum Wittm (Caryocaraceae), popularly known as pequi, has wide applications in popular medicine. Preclinical tests have demonstrated the therapeutic properties of the oil. We investigated the antinociceptive and anti-inflammatory effects of Pequi C. coriaceum Wittm ethyl acetate extract (PCCO) on zymosan-induced arthritis in rat knee joint. The animals were pretreated with PCCO for 7 consecutive days or with a single dose. Paw elevation time (PET), leukocyte infiltration, myeloperoxidase activity (MPO) and cytokine levels were assessed 4h after zymosan injection. Synovial tissue was harvested for immunohistochemical analysis, edema and vascular permeability. We observed a significant decrease in PET with PCCO pretreatment. PCCO showed a significant reduction of leukocyte migration and a decrease in MPO. Decreases were observed in cytokine release in the synovial fluid and TNF-α and cyclooxygenase-1 immunostaining in synovial tissue. Edema was inhibited by treatment with all doses of PCCO. The data suggest that PCCO exerts antinociceptive and anti-inflammatory effects on arthritis in rats.

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Citations

Jun 21, 2016·Journal of Ethnopharmacology·Patrícia Rosane Leite de FigueiredoIrwin Rose de Alencar Menezes
Feb 8, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A C A MouraM B S Maia
Jul 19, 2019·Journal of Toxicology and Environmental Health. Part a·Sandra Mara DuavyNilda Vargas Barbosa
Feb 2, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Germanna M BarbosaTania F Salvini
Dec 2, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Lucinéia Reuse AlbieroYara Maria Lucisano-Valim
Apr 10, 2019·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Armando Jorge JuniorCândida Aparecida Leite Kassuya

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