Antinociceptive and antidepressant like effects of Securidaca longepedunculata root extract in mice

Journal of Ethnopharmacology
R A AdebiyiE U Etuk

Abstract

The aqueous root extract of Securidaca longepedunculata (polygalaceae) was investigated for possible antinociceptive and central nervous system (CNS) effects in mice. Three nociceptive models; acetic acid, formalin and tail-flick tests were used to study the antinociceptive activity. Rectal temperature test was employed as an adjunct to the nociceptive models. The extract at 200 and 400 mg/kg significantly and dose dependently reduced the nociception induced by the acetic acid and in the early phase of formalin test (P<0.05). The extract exerted significant (P<0.05) hypothermic effect in the 15 and 30 min of the rectal temperature test. The antinociceptive and hypothermic effects were partially reversed by naloxone (1mg/kg). The tail-flick test produced an insignificant increase in tail-flick latency at 400 mg/kg after 60 min of the test, but significantly (P<0.05) increase tail-flick latency in the 400mg/kg group of animals pre-treated with naloxone (1 mg/kg) after 120 min of the test. The extract also produced a significant (P<0.05) naloxone reversible antidepressant like effect in the forced swimming test (an animal model of depression). Collectively, these results suggest that the extract possess antinociceptive and antidep...Continue Reading

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Citations

Jan 1, 2011·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Fleur Clarisse Moto OkomoloSilvère Vincent Rakotonirira
Jun 16, 2015·Epilepsy & Behavior : E&B·Nikolaus J Sucher, Maria C Carles
Jul 22, 2008·Journal of Ethnopharmacology·J J Marion MeyerA A Hussein
Oct 24, 2007·Peptides·Richard J Bodnar
Feb 27, 2015·Reviews in the Neurosciences·Marzieh Sarbandi FarahaniRoja Rahimi
Jan 13, 2021·Planta medica·Inés Moragrega, José Luis Ríos
May 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jeanette Martins, Brijesh S

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