Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
E M DavidsonJ E Chelly


To assess the role of esmolol, a beta1 receptor blocker, in the modulation of pain in the absence of anesthesia. Rats were chronically instrumented to record mean arterial blood pressure (MAP) and heart rate (HR). Animals were divided into three groups. Group 1 [esmolol high (EH) 150 mg x kg(-1) x hr(-1); n = 9], Group 2 [esmolol low (EL) 40 mg x kg(-1) x hr(-1); n = 7] and Group 3 saline (n = 9). Formalin 5% was injected in the rat hind paw. Formalin-induced lifting, MAP and HR were recorded at five minute intervals for 35 min after formalin injection. Formalin was associated with an early (Phase 1; 0-5 min) and late nociceptive response (Phase 2; 10-35 min). Esmolol did not affect Phase 1. Although low dose esmolol had minimum effects on nociceptive Phase 2, it was diminished with high dose esmolol. Formalin induced biphasic increases in MAP and HR. Although esmolol did not affect the initial increase in MAP, high dose esmolol blunted the secondary increase in MAP Both low and high doses of esmolol inhibited formalin-induced tachycardia during the first 30 min. Our data suggest that esmolol leads to analgesia and reduction of cardiovascular responses to pain.


Oct 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K S ChungD G Silverman
Oct 1, 1992·Pain·A TjølsenK Hole
Nov 1, 1991·British Journal of Pharmacology·F Q CunhaS H Ferreira
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·A Randich, William Maixner
Apr 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R KorpinenS Sarna
Aug 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S SharmaR Kalra
Aug 1, 1997·Anesthesiology·D Baranov, R J Bagshaw


Aug 29, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Homer Yang, Ashraf Fayad
Mar 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hang ZhaoSatoshi Kashimoto
Feb 23, 2010·Journal of Anesthesia·Tsutomu OshimaYoshiko Kasuya
Mar 3, 2012·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Servando López-ÁlvarezRafael Blanco-Dávila
Dec 12, 2013·CNS Drugs·Leandro Francisco Silva Bastos, Márcio Matos Coelho
Oct 31, 2007·Journal of Clinical Anesthesia·Belgin YavascaogluBerin Ozcan
Oct 17, 2012·European Journal of Pain : EJP·P SchweinhardtFranco Carli
Oct 13, 2015·The Journal of Pain : Official Journal of the American Pain Society·Loren J MartinWilliam Maixner
Apr 26, 2006·Best Practice & Research. Clinical Anaesthesiology·Bruno Guignard
Sep 4, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Ritima DhirRipul Oberoi
Apr 5, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Sepideh VahabiAbolfazl Abbas Zadeh
Nov 25, 2003·Anesthesia and Analgesia·Paul F WhiteAlexander Sloninsky
Nov 29, 2011·The Journal of International Medical Research·Y E MoonJ Lee
Sep 30, 2010·Korean journal of anesthesiology·Yoon Hee Kim
Sep 15, 2018·Regional Anesthesia and Pain Medicine·Marshall P Bahr, Brian A Williams
Sep 18, 2010·Journal of Clinical Nursing·Shu-Fen Chen, Chiu-Chu Lin
Aug 28, 2013·Anaesthesia and Intensive Care·K ShettyK Byth
Feb 16, 2013·American Journal of Therapeutics·Hitomi OnoEiji Masaki

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Esmolol hydrochloride
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