Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen

Journal of Ethnopharmacology
Qizhi ZhaoKejun Wang

Abstract

Lindera angustifolia Chen is a folk medicine used for the treatment of contusions-induced swelling, rheumatic pains and bellyache in south and the middle part of China. Phytochemical studies showed that aporphine and benzyltetrahydroisoquinoline alkaloids are the characteristic constituents of this plant. In this study, we evaluated the antinociceptive and free radical scavenging properties of six aporphine and two benzyltetrahydroisoquinoline alkaloids isolated from the root of Lindera angustifolia. All alkaloids except magnocurarine exhibited remarkable radical scavenging effects (36-90% scavenging at 25-100microg/ml) in DPPH radical scavenging test, among them norisocorydine showed the hightest activity (SC(50): 14.1microg/ml). Antinociceptive activities were tested by using acetic acid-induced writhing and formalin test at dose of 20mg/kg. Norisocorydine exhibited the highest antinociceptive ability with 83.5% writhing inhibition. Boldine, norboldine showed significant antinociceptive activity with 76.3% and 74.6% writhing inhibition respectively. Indomethacin was used as positive control, which showed 67.8% writhing inhibition at dose of 10mg/kg. Most of the compounds, except N-ethoxycarbonyllaurotetanine and magnocurarine...Continue Reading

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Citations

Aug 27, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Miloš HrochPavel Tomšík
Nov 2, 2011·Journal of Natural Products·Frédéric MartinRohan A Davis
Dec 24, 2011·Journal of Medicinal Food·Flávia V Santa-CecíliaMarcelo H Dos Santos
Jan 31, 2014·Journal of Medicinal Food·Maria Eliza Castro MoreiraMarcelo Henrique dos Santos
Oct 24, 2012·Journal of Biomedicine & Biotechnology·Marcela Hernández-OrtegaHugo Necoechea-Mondragón
Oct 11, 2008·Phytotherapy Research : PTR·Lip Yong ChungZamrie Imiyabir
Nov 9, 2016·Natural Product Research·Jie-Ping LeiHe-Zhong Jiang
Apr 30, 2013·International Journal of Molecular Sciences·Chung-Ping YangYueh-Hsiung Kuo
Apr 8, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lau Yeh-SiangMohd Rais Mustafa
Mar 9, 2007·Journal of Natural Products·Xian-Wen YangXiao-Jiang Hao

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