Antinociceptive constituents from Saccharum officinarum L. juice.

Natural Product Research
Anne C C GomesRicardo M Kuster

Abstract

This work aimed to investigate the main components of methanol fractions (MFSC and MFSCf) from Saccharum officinarum L. juice and their in vivo antinociceptive potential. After LC-ESI-MS and ESI-MS/MS analysis, phenolic compounds, such as dicaffeoylquinic acid, schaftoside, vicenin-2, stilbene glycoside and the major compound tricin-7-O-(2″- α-L-rhamnopyranosyl)-α-D-galacturonide (1), were identified. MFSC and MFSCf significantly inhibited nociceptive responses in classical mice pain models. The isolated flavone, 1, inhibited strongly the neurogenic phase in formalin test without interfering with the inflammatory one. The co-administration of the opioid antagonist, naloxone, significantly reversed the antinociceptive effects on the neurogenic phase of both methanol fractions and 1, demonstrating the involvement of the opioid system on the antinociceptive effect. This work describes for the first time the antinociceptive effect of flavonoids present in sugarcane juice, highlighting the isolation and the structural elucidation of tricin-7-O-(2″-α-L-rhamnopyranosyl)-α-D-galacturonide through ESI-MS/MS, 1D- and 2D-NMR.

References

Feb 1, 1990·Journal of Ethnopharmacology·P ThirugnanasambanthamL Kameswaran
Jul 14, 2010·Journal of Ethnopharmacology·Sarahbelle Leitte CartaxoUlysses Paulino de Albuquerque
May 4, 2013·Pharmacology, Biochemistry, and Behavior·Umide Demir Özkay, Ozgür Devrim Can
Dec 30, 2014·Archives of Toxicology·Elizabeth M LancasterAli Zarrinpar

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