Antinociceptive Diterpenoids from the Leaves and Twigs of Rhododendron decorum

Journal of Natural Products
Yu-Xun ZhuYong Li

Abstract

Three new leucothane-type (1-3), two new micrathane-type (4, 5), eight new grayanane-type diterpenoids (6-13), and four known compounds were obtained from the ethanol extract of the leaves and twigs of Rhododendron decorum. The structures were determined based on NMR spectra, quantum chemical calculations, and X-ray crystallography. The antinociceptive activities of compounds 1, 3, 4, 6, 8, 10-13, and 15-17 were evaluated via the acetic acid-induced writhing test. Compounds 1, 8, 11-13, and 15 exhibited significant antinociceptive activities. In particular, 12 and 15 were found to be effective at doses of 0.8 and 0.08 mg/kg, respectively.

References

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Citations

Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chen-Yu QianChao-Chan Li
Dec 3, 2021·Journal of Asian Natural Products Research·Guo-Sheng LiuYong Li

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