Antinociceptive effect of (-)-α-bisabolol in nanocapsules

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Gisele Façanha Diógenes TeixeiraAdriana Rolim Campos

Abstract

This study aimed to develop and to evaluate the antinociceptive effect of a drug delivery system containing (-)-α-bisabolol (BISA). Nanocapsules containing BISA (BISA-NC) were prepared using acetylated galatomannan. Particle size distribution was determined by atomic force microscopy, zeta potential measurement and photon correlation spectroscopy. Corneal nociception was induced by topical application of 5M NaCl and the nociceptive behavior was characterized by eye wiping in mice. Molecular docking was conducted on the TRPV1 channel. Nanocapsules showed mean particle sizes between 94.44 and 105.44nm and the zeta potential of was -1.34mV. Animals pretreated with BISA-NC (200mg/mL) had a significant reduction (**p<0.01) in the number of nociceptive behaviors. Docking study indicated an interaction between BISA and TRPV1. This study indicates that BISA-NC may be useful for producing eye drops for the treatment of ocular pain.

Citations

Dec 1, 2017·Scientific Reports·Abdul Hafeez, Imran Kazmi
Aug 29, 2018·Zebrafish·Francisco Ernani Alves MagalhãesAdriana Rolim Campos
Jul 8, 2020·AAPS PharmSciTech·Tatianny de Araujo AndradeMairim Russo Serafini
Jun 18, 2020·Frontiers in Pharmacology·Davidson Barbosa AssisReinaldo Nóbrega de Almeida
Apr 16, 2021·Canadian Journal of Physiology and Pharmacology·Mario I OrtizGilberto Castañeda-Hernández

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