Antinociceptive effect of a novel tosylpyrazole compound in mice

Basic & Clinical Pharmacology & Toxicology
Sara Marchesan OliveiraJuliano Ferreira

Abstract

Pain is the most common complaint in the medical field and the identification of compounds that can effectively treat painful states without induction of side-effects remains a major challenge in biomedical research. The aim of the present study was to investigate the antinociceptive effect of a novel compound, 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole (compound A) in several models of pain in mice and compare with those produced by the known trifluoromethyl-containing pyrazole compound celecoxib. Compound A or celecoxib were administrated by oral (78-780 micromol/kg), intrathecal (9-22.5 nmol/site) or intracerebroventricular (9-22.5 nmol/site) routes. Oral administration of either compound A or celecoxib abolished the mechanical allodynia, but not the oedema caused by intraplantar injection of carrageenan. Similarly, compound A reduced the overt nociception, but not the oedema, produced by bradykinin or capsaicin. However, compound A (500 micromol/kg, orally) did not alter nociception nor oedema caused by intraplantar injection of prostaglandin E(2 )or glutamate, whereas celecoxib reduced only the nociception induced by the former. Moreover, oral and intrathecal administration of compound A or celecoxib also redu...Continue Reading

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Citations

May 3, 2013·PLoS Neglected Tropical Diseases·Camila GewehrMarcus V Gomez
Apr 12, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Gabriela TrevisanJuliano Ferreira
Jun 23, 2009·Pharmacology, Biochemistry, and Behavior·Ethel A WilhelmLucielli Savegnago
Jul 16, 2011·European Journal of Pharmacology·Natasha Frasson PavinLucielli Savegnago
Jul 19, 2011·Pharmacology, Biochemistry, and Behavior·Camila GewehrJuliano Ferreira
Jul 23, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Laís da Rosa MoreiraRicardo Brandão
Jun 21, 2016·Journal of Ethnopharmacology·Evelyne da Silva BrumSara Marchesan Oliveira
Aug 13, 2017·Inflammopharmacology·Susana Paula Moreira FischerSara Marchesan Oliveira
Jul 28, 2012·The Journal of Pharmacology and Experimental Therapeutics·Gabriela TrevisanJuliano Ferreira
Aug 20, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Cristiani Isabel Banderó WalkerGabriela Trevisan
Jul 26, 2017·The Biochemical Journal·Maria Fernanda Pessano FialhoSara Marchesan Oliveira

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