PMID: 9180346Jan 1, 1997Paper

Antinociceptive effect of buprenorphine in mu1-opioid receptor deficient CXBK mice

Life Sciences
J KameiH Nagase

Abstract

The antinociceptive effect of buprenorphine was examined in mu1-opioid receptor-deficient CXBK mice. I.p. administration of buprenorphine at a dose of 3 mg/kg produced marked antinociception in the tail-flick test in C57BL/6 mice, a progenitor strain of CXBK mice. The antinociceptive effect of buprenorphine in C57BL/6 mice was antagonized by pretreatment with either beta-funaltrexamine (beta-FNA), a mu-opioid receptor antagonist, or naloxonazine (NXZ), a selective mu1-opioid receptor antagonist. The antinociceptive effect of buprenorphine (3 mg/kg, i.p.) in CXBK mice was significantly less than that in C57BL/6 mice. Neither beta-FNA nor NXZ reduced the antinociceptive effect of buprenorphine in CXBK mice. There was no significant difference between the buprenorphine-induced antinociceptive effect in CXBK mice and NXZ-treated C57BL/6 mice. Furthermore, neither naltrindole, a selective delta-opioid receptor antagonist, nor norbinaltorphimine, a selective kappa-opioid receptor antagonist, had a significant effect on the antinociceptive effects of buprenorphine in both CXBK and C57BL/6 mice. These results support our previous hypothesis that mu1- rather than mu2-, delta- or kappa-opioid receptors are involved in the antinociceptive...Continue Reading

References

Aug 15, 1975·Life Sciences·A BaranD W Bailey
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Citations

Jul 13, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mellar P Davis
Jun 5, 2003·Biochemical Pharmacology·Gang WeiChun Su Yuan
Nov 5, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M D'EliaJ Bernier
Apr 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Soichiro IdeKazutaka Ikeda
Sep 6, 2005·European Journal of Pain : EJP·Babette KögelElmar Friderichs
Oct 1, 2013·Pharmacological Reviews·Gavril W Pasternak, Ying-Xian Pan
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Hirokazu MizoguchiLeon F Tseng
Apr 23, 2013·Fundamental & Clinical Pharmacology·Manish Manohar AglaweNandkishor Ramdas Kotagale

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