Antinociceptive effect of butyl (2-phenylethynyl) selenide on formalin test in mice: Evidences for the involvement of serotonergic and adenosinergic systems

European Journal of Pharmacology
Cristiane LucheseCristina W Nogueira

Abstract

The present study investigated the effect of per oral (p.o.) administration of butyl (2-phenylethynyl) selenide (1-50mg/kg) on formalin-induced nociception in mice. The involvement of serotonergic, adenosinergic, muscarinic cholinergic and opioid mechanisms in the antinociceptive effect was also investigated. Butyl (2-phenylethynyl) selenide inhibited both neurogenic (at doses equal or higher than 10mg/kg) and inflammatory (at doses equal or higher than 25mg/kg) phases of the nociception caused by intraplantar (i.pl.) injection of 2.5% formalin solution (20 microl), with ID(50) values of 36.7 (29.28-46.0) and 20.37 (15.74-26.36) mg/kg, respectively. This compound reduced the formalin-induced paw oedema formation (55 + or - 4%) at doses equal or higher than 25mg/kg. The antinociceptive effect of compound (25mg/kg, p.o.) was reversed by ondansetron (0.5mg/kg, a 5-HT(3) receptor antagonist) and caffeine (3mg/kg, a nonselective adenosine receptor antagonist), but not by atropine (0.1mg/kg, a non selective muscarinic antagonist), WAY100635 (0.1mg/kg, a selective 5-HT(1A) receptor antagonist), ritanserin (1mg/kg, a 5-HT(2) receptor antagonist) and naloxone (1mg/kg, a non selective opioid receptor antagonist). These results indicate t...Continue Reading

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Citations

Jul 16, 2011·European Journal of Pharmacology·Natasha Frasson PavinLucielli Savegnago
Oct 1, 2013·Pharmaceutical Biology·Masoud MahamGhader Jalilzadeh-Amin
Oct 27, 2016·Neuroscience·J Sawynok
Apr 3, 2013·European Journal of Pharmacology·Rakesh B PatelMukul R Jain
May 26, 2017·Fundamental & Clinical Pharmacology·Vanessa D G SilvaEthel A Wilhelm
Mar 28, 2018·The Journal of Pharmacy and Pharmacology·Roberta Gonçalves AnversaLucielli Savegnago
May 13, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rami AyoubZainul Zakaria

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