Antinociceptive effect of extracts and compounds from Hofmeisteria schaffneri

Journal of Ethnopharmacology
Guadalupe Angeles-LópezRachel Mata

Abstract

Hofmeisteria schaffneri (Asteraceae) is a medicinal plant widely commercialized in the most important Markets of Mexico City for the treatment of gastro-intestinal complaints and skin afflictions. The main goals of this study were to establish the potential acute toxicity and the antinociceptive activity in animal models of several preparations and compounds from Hofmeisteria schaffneri. The aqueous and organic extracts as well as the essential oil of Hofmeisteria schaffneri were prepared by infusion, maceration and hydrodistillation, respectively. Investigation of the acute toxicity was accomplished by the Lorke method. The antinociceptive effect was assessed using the writhing and the hot plate tests. Natural compounds were isolated by standard phytochemical procedures. In addition, a few thymol esters were prepared by chemical synthesis. The stability of natural and synthetic esters was qualitatively analyzed by measuring their susceptibility to hydrolysis by pig liver estearase and mouse plasma at 37 degrees C. The LD(50) for each preparation tested was higher than 5000 mg/kg revealing that they were not toxic to mice after exposure for short space of time. On the other hand, the extracts showed significant antinociceptive ...Continue Reading

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Mar 11, 2008·Phytochemistry·Araceli Pérez-VásquezRachel Mata

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Citations

Dec 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José Ferreira Sarmento-NetoDamião Pergentino de Sousa
Oct 11, 2011·Peptides·Richard J Bodnar
Mar 16, 2011·The Journal of Pharmacy and Pharmacology·Araceli Pérez-VásquezRachel Mata
Jan 9, 2013·Phytotherapy Research : PTR·Adriana G GuimarãesLucindo J Quintans
Dec 14, 2017·International Journal of Molecular Sciences·Rita de Cássia da Silveira E SáDamião Pergentino de Sousa
Mar 9, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Damião Pergentino de Sousa
May 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ze-Jun Wang, Thomas Heinbockel

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