Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats

Scientific Reports
Yue LiuXiaoping Gu

Abstract

Caloric restriction (CR) increases lifespan, retards physiological signs of aging, and delays a variety of diseases. Reduction of inflammatory response was proposed as one of the molecular mechanisms for how CR exerts beneficial effects. The present study investigated the effects of CR on postoperative pain in rats. Adult nonobese rats were divided into two dietary groups, an ad libitum fed group (AL) and a caloric restriction group (CR) that was provided with 60% of the food intake of AL rats. After 6 weeks, the effects of CR on pain behaviors and inflammation induced by plantar incision were examined. CR rats displayed significantly reduced nonevoked pain, mechanical allodynia and thermal hyperalgesia induced by incision, and showed decreased levels of pro-inflammatory cytokines in serum, peri-incisional skin tissue and ipsilateral spinal cord dorsal horn at 6 h and 24 h after incision. The analgesic efficiency of parecoxib and morphine, two agents widely used for the management of postoperative pain clinically, was reinforced by CR. Together, CR generates antinociceptive effects on postoperative incisional pain in rats, perhaps providing some improvement of QOL in patients with postoperative pain, and the beneficial effects ...Continue Reading

References

Mar 1, 1996·Pain·T J BrennanG F Gebhart
Oct 28, 1999·Neurobiology of Aging·T D PughR Weindruch
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Otilia ObrejaMichaela Kress
Feb 6, 2003·Genes & Development·Jana Koubova, Leonard Guarente
Nov 5, 2003·British Journal of Pharmacology·Garth T WhitesideKatharine Walker
Apr 23, 2004·European Journal of Pharmacology·Satyanarayana S V PadiShrinivas K Kulkarni
Mar 22, 2005·Pain·Walter A Hargraves, Ian D Hentall
Dec 13, 2005·Critical Care Medicine·Charles A Dinarello
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·G López-LluchR de Cabo
Aug 29, 2006·Free Radical Biology & Medicine·Janet W RankinKorinn E Saker
Mar 7, 2007·CNS Drugs·Srinivas Pyati, Tong J Gan
Aug 4, 2007·Physiology & Behavior·Elizabeth A LevayStephen Kent
Apr 9, 2008·The Journal of Pain : Official Journal of the American Pain Society·Brendan CarvalhoMartin S Angst
Sep 19, 2008·Experimental Gerontology·Danica ChenLeonard Guarente
Apr 4, 2009·Experimental Neurology·Anne M SkoffJoshua E Adler
Aug 15, 2009·Brain, Behavior, and Immunity·Mark R HutchinsonLinda R Watkins
Dec 17, 2009·Anesthesiology·Paul F White, Henrik Kehlet
Jun 12, 2010·The Journal of Surgical Research·Tessa M van GinhovenJan N M IJzermans
Sep 9, 2010·Anesthesiology·De-Yong LiangJ David Clark
Apr 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leah MacDonaldStephen Kent
Dec 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Salvatore FuscoGiovambattista Pani
May 24, 2012·Anesthesiology·Christina M Spofford, Timothy J Brennan
May 25, 2013·Nature Reviews. Immunology·Eicke LatzAndrea Stutz
Sep 24, 2013·Immunity·Haitao WenJenny P-Y Ting
May 16, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Winfried HäuserAnja Hilbert
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Célia A AveleiraCláudia Cavadas
Jun 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Peter M GraceLinda R Watkins

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Citations

Jun 23, 2020·Expert Opinion on Therapeutic Targets·Jo NijsAnneleen Malfliet
Nov 16, 2019·Scientific Reports·Jeong-Yun LeeSeog Bae Oh
Dec 6, 2019·Peptides·Richard J Bodnar
Oct 17, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Cosmin I Ciotu, Michael J M Fischer

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BETA
acetylation
ELISA

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SPSS

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