Antinociceptive effects of intracerebroventricular administration of guanine-based purines in mice: evidences for the mechanism of action

Brain Research
A P SchmidtD O Souza

Abstract

It is well known that adenine-based purines exert multiple effects on pain transmission. However, less attention has been given to the potential effects of guanine-based purines (GBPs) on pain transmission. The aim of this study was to investigate the effects of intracerebroventricular (i.c.v.) guanosine and GMP on mice pain models. Mice received an i.c.v. injection of vehicle (saline or 10 muM NaOH), guanosine (5 to 400 nmol), or GMP (240 to 960 nmol). Additional groups were also pre-treated with i.c.v. injection of the A(1)/A(2A) antagonist caffeine (15 nmol), the non-selective opioid antagonist naloxone (12.5 nmol), or the 5'-nucleotidase inhibitor AOPCP (1 nmol). Measurements of CSF purine levels and cortical glutamate uptake were performed after treatments. Guanosine and GMP produced dose-dependent antinociceptive effects. Neither caffeine nor naloxone affected guanosine antinociception. Pre-treatment with AOPCP completely prevented GMP antinociception, indicating that conversion of GMP to guanosine is required for its antinociceptive effects. Intracerebroventricular administration of guanosine and GMP induced, respectively, a 180- and 1800-fold increase on CSF guanosine levels. Guanosine was able to prevent the decrease o...Continue Reading

References

Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·D J CalcagnettiS G Holtzman
May 1, 1989·Trends in Pharmacological Sciences·J SawynokT D White
Aug 1, 1996·Current Opinion in Neurobiology·G Burnstock, J N Wood
Jan 1, 1997·Advances in Pharmacology·J M Brundege, T V Dunwiddie
Jan 1, 1997·Acta Anaesthesiologica Scandinavica. Supplementum·A Sollevi
Feb 26, 1998·Pharmacology, Biochemistry, and Behavior·T SakuradaK Kisara
Jul 3, 1998·European Journal of Pharmacology·J Sawynok
Feb 13, 1999·Progress in Neurobiology·M J Millan
Mar 8, 2000·Progress in Neurobiology·J F HerreroJ A López-García
May 4, 2000·Brain Research·A P SchmidtD Onofre Souza
Aug 16, 2000·Neuroreport·R RoeslerD O Souza
Oct 31, 2000·Neurochemical Research·M B LealE Elisabetsky
May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R CiccarelliP Di Iorio
Feb 28, 2002·British Journal of Pharmacology·Ugo TraversaMichel P Rathbone
Dec 10, 2002·Cellular and Molecular Neurobiology·Marcos Emílo dos Santos FrizzoDiogo Onofre Souza
Feb 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yongmei Chen, Raymond A Swanson
Apr 25, 2003·Brain Research·Marcos Emílio dos Santos FrizzoDiogo Onofre Souza
Jun 6, 2003·Progress in Neurobiology·Jana Sawynok, Xue Jun Liu
Jun 6, 2003·Brain Research·Elsa Regina VinadéDiogo Onofre Souza
Dec 4, 2003·Bioorganic & Medicinal Chemistry·Ugo TraversaRoberto Pellicciari
Mar 3, 2004·Neurobiology of Learning and Memory·Elsa Regina VinadéDiogo Onofre Souza
Mar 27, 2004·Brain Research·Félix A SoaresDiogo O Souza
Nov 24, 2004·Journal of Neuroscience Research·Elsa R VinadéDiogo O Souza
Dec 6, 2005·Neurobiology of Learning and Memory·Jonas Alex Morales SauteMarcelo Ganzella
Jan 3, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Leszek DomanskiKazimierz Ciechanowski
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock

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Citations

Oct 15, 2011·Acta Veterinaria Scandinavica·Joanna CzarneckaMichał Komoszyński
Dec 15, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marcelo GanzellaDiogo Onofre Souza
Dec 30, 2015·European Journal of Pharmacology·Enderson D de OliveiraAndré P Schmidt
Jun 23, 2010·Pharmacology, Biochemistry, and Behavior·Roberto Farina AlmeidaMarcelo Ganzella
Sep 8, 2009·The Journal of Pain : Official Journal of the American Pain Society·André P SchmidtDiogo O Souza
Apr 22, 2009·European Journal of Pharmacology·André P SchmidtDiogo O Souza
Oct 17, 2012·Cell Biochemistry and Function·Lucas PanizDiogo O Souza
Feb 6, 2010·British Journal of Pharmacology·A P SchmidtD O Souza
Mar 24, 2016·Purinergic Signalling·Luis E B BettioAna Lúcia S Rodrigues
Jul 12, 2011·Pharmacology, Biochemistry, and Behavior·Robson PachecoCarina Rodrigues Boeck
Jul 6, 2016·Frontiers in Pharmacology·Valentina Di LibertoNatale Belluardo
Oct 5, 2016·Aging and Disease·Débora LanznasterCarla I Tasca
Jul 22, 2008·Arquivos de neuro-psiquiatria·Henrique Cerqueira GuimarãesPaulo Caramelli
Nov 22, 2018·Frontiers in Cellular Neuroscience·Carla I TascaFrancisco Ciruela
Oct 2, 2009·Peptides·Richard J Bodnar

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