Antinociceptive effects of vitexin in a mouse model of postoperative pain

Scientific Reports
Qing ZhuJun-Xu Li

Abstract

Vitexin, a C-glycosylated flavone present in several medicinal herbs, has showed various pharmacological activities including antinociception. The present study investigated the antinociceptive effects of vitexin in a mouse model of postoperative pain. This model was prepared by making a surgical incision on the right hindpaw and von Frey filament test was used to assess mechanical hyperalgesia. Isobolographical analysis method was used to examine the interaction between vitexin and acetaminophen. A reliable mechanical hyperalgesia was observed at 2 h post-surgery and lasted for 4 days. Acute vitexin administration (3-10 mg/kg, i.p.) dose-dependently relieved this hyperalgesia, which was also observed from 1 to 3 days post-surgery during repeated daily treatment. However, repeated vitexin administration prior to surgery had no preventive value. The 10 mg/kg vitexin-induced antinociception was blocked by the opioid receptor antagonist naltrexone or the GABAA receptor antagonist bicuculline. The doses of vitexin used did not significantly suppress the locomotor activity. In addition, the combination of vitexin and acetaminophen produced an infra-additive effect in postoperative pain. Together, though vitexin-acetaminophen combina...Continue Reading

References

Apr 1, 1989·The Journal of Clinical Endocrinology and Metabolism·E GaitanK Kubota
Dec 1, 1981·Planta medica·M C PrabhakarM S Khan
Apr 1, 1995·The Journal of Clinical Endocrinology and Metabolism·E GaitanR H Lindsay
Feb 19, 2002·Journal of Ethnopharmacology·Yao Lan LiPaul Pui-Hay But
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
May 30, 2002·Progress in Neurobiology·Mark J Millan
Sep 26, 2003·Anesthesiology·Esther M Pogatzki, Srinivasa N Raja
Apr 28, 2004·European Journal of Pain : EJP·Laurent Bardin, Francis C Colpaert
Oct 13, 2004·European Journal of Pharmacology·Chang Young JeongMyung Ha Yoon
Mar 26, 2005·Archives of Pharmacal Research·Jin Hwa KimHyeong Bae Pyo
Oct 18, 2005·European Journal of Pharmacology·Ivan KissFrancis C Colpaert
Jul 21, 2009·Trends in Pharmacological Sciences·Hanns Ulrich ZeilhoferAlessandra Di Lio
Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·YingJun ZhouY Eric Shi
Feb 1, 2011·Journal of Ethnopharmacology·S GorzalczanyG Ferraro
Oct 18, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Liuyi DongZhiwu Chen
Nov 8, 2011·Pain·Sylvia ReichlEsther M Pogatzki-Zahn
May 5, 2012·Chemical Biology & Drug Design·Esmail AbbasiMehdi Sheikhi
Sep 15, 2012·Phytotherapy Research : PTR·Shih-Huang YangMing-Yung Chou
Oct 27, 2012·European Journal of Pharmacology·Özgür Devrim CanUmut İrfan Üçel
Dec 19, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·R PraveenaRaman Sivakumar
Apr 30, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Cui-cui LuZhi-min Du
May 4, 2013·Pharmacology, Biochemistry, and Behavior·Umide Demir Özkay, Ozgür Devrim Can
Jun 8, 2013·Journal of Natural Products·Sergio M BorghiWaldiceu A Verri
Feb 4, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiaqi WuHong Zhou
Feb 18, 2014·Neurochemical Research·Kenneth E McCarson, S J Enna
Apr 1, 2010·Current Therapeutic Research, Clinical and Experimental·Halit MadenoğluAdem Boyaci
Apr 24, 2014·Anesthesia and Analgesia·Peyman SahbaieJ David Clark
Mar 31, 2015·The Surgical Clinics of North America·Jessica Lovich-SapolaChristopher P Brandt
Apr 4, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yanan WangLiuyi Dong

❮ Previous
Next ❯

Citations

Apr 6, 2018·Current Pain and Headache Reports·Sukanya MitraNalini Vadivelu
May 17, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ajeet Kumar SinghManjula Vinayak
Apr 25, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Zainul Amiruddin ZakariaArifah Abdul Kadir
Feb 19, 2019·International Journal of Food Sciences and Nutrition·Concetta SchianoClaudio Napoli
Feb 3, 2018·Pain Reports·Esther M Pogatzki-ZahnStephan A Schug
Jul 5, 2016·Journal of Neuroscience Research·Nicole E BurmaTuan Trang
Jun 24, 2020·Environmental Analysis, Health and Toxicology·Nathaniel Ohiemi Amedu, Gabriel Olaiya Omotoso
Mar 17, 2020·Journal of Ethnopharmacology·Adarly KrothWania Aparecida Partata
Apr 10, 2019·European Journal of Pharmacology·Elham SameiyanGholamreza Karimi
Jul 3, 2021·International Journal of Molecular Sciences·Martina TremmelJörg Heilmann

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.