Antinociceptive potentiation and attenuation of tolerance by intrathecal co-infusion of magnesium sulfate and morphine in rats

Anesthesia and Analgesia
Robert J McCarthyA D Ivankovich

Abstract

N-methyl-D-aspartate (NMDA) antagonists, such as MK801, delay the development of morphine tolerance. Magnesium, a noncompetitive NMDA antagonist, reduces postoperative morphine requirements. The present study was designed to evaluate the effects of intrathecal co-administration of magnesium sulfate with morphine on antinociceptive potentiation, tolerance, and naloxone-induced withdrawal signs. Magnesium sulfate (40-60 microg/h) co-administration for 7 days, similar to MK801 (10 nmol/h), prevented the decline in antinociceptive response compared with morphine (20 nmol/h). Magnesium sulfate (60 microg/h) produced no antinociception, but co-infused with morphine (1 nmol/h), it resulted in potentiated antinociception compared with morphine throughout the 7-day period. Probe morphine doses after 7-day infusions demonstrated a significantly greater 50% effective dose value for morphine 1 nmol/h (109.7 nmol) compared with saline (10.9 nmol), magnesium sulfate 60 microg/h (10.9 nmol), and magnesium sulfate 60 microg/h plus morphine 1 nmol/h (11.2 nmol), which indicates that magnesium had delayed morphine tolerance. Morphine withdrawal signs after naloxone administration were not altered by the co-infusion of magnesium sulfate. Cerebros...Continue Reading

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Citations

Aug 4, 2012·International Journal of Obstetric Anesthesia·Jiehao SunRiyong Zhou
Jun 21, 2011·Clinical and Experimental Pharmacology & Physiology·L K GuptaC D Tripathi
Dec 5, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Alain C Van ElstraeteDan Benhamou
May 24, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Fatemeh GhasemiKambiz Hassanzadeh
Jan 19, 2010·Pharmacological Reports : PR·Magdalena BujalskaStanisław W Gumułka
Feb 1, 2011·Free Radical Biology & Medicine·Daniela SalveminiWilliam L Neumann
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Feb 19, 2017·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Jessica Castro, Maureen F Cooney
Nov 26, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Magdalena Bujalska-ZadrożnyMarek Naruszewicz
May 23, 2003·Anesthesia and Analgesia·Chung-Ren LinJiin-Tsuey Cheng
Apr 23, 2003·Anesthesia and Analgesia·Asokumar BuvanendranKenneth J Tuman
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Mar 3, 2011·Anesthesiology·Susanne HerroederMarkus W Hollmann

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