Antinuclear antibodies (ANA) in chronic hepatitis C virus infection: correlates of positivity and clinical relevance

Journal of Viral Hepatitis
L J YeeM R Thursz

Abstract

We examined correlates of antinuclear antibody (ANA) positivity (ANA+) in individuals with chronic hepatitis C virus (HCV) infection and the effect of positivity on clinical outcome of HCV. Pretreatment sera from 645 patients from three centres in Sweden (n = 225), the UK (n = 207) and Italy (n = 213) were evaluated by indirect immunofluorescence on Hep-2 cells for ANA pattern and titre by a single laboratory. Liver biopsies were all scored by one pathologist. A total of 258 patients were subsequently treated with interferon monotherapy. There was a significant difference in the prevalence of ANA (1:40) by geographic location: Lund 4.4%, London 8.7%, Padova 10.3% [odds ratio (OR) = 0.66; 95% CI: 0.46-0.94; P = 0.023]. Duration of HCV infection, age at infection, current age, route of infection, viral genotype, alcohol consumption, fibrosis stage and inflammatory score were not correlated with ANA+ or ANA pattern. Female gender was correlated with ANA+ and this association persisted in multivariable analyses (OR = 3.0; P = 0.002). Increased plasma cells were observed in the liver biopsies of ANA-positive individuals compared with ANA-negative individuals, while a trend towards decreased lymphoid aggregates was observed [hazard r...Continue Reading

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jan 1, 1995·Gastroenterology·A J CzajaS B Moore
Feb 1, 1997·Seminars in Arthritis and Rheumatism·R W McMurray, K Elbourne
Aug 1, 1997·Digestive Diseases and Sciences·A J CzajaF B Bianchi
Jul 29, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D ZauliF B Bianchi
Jan 6, 2000·Journal of Hepatology·M P Manns, E G Rambusch
Aug 30, 2001·Nature Immunology·C C Whitacre
Jul 18, 2002·International Journal of Dermatology·Kanokvalai KulthananApichati Sivayathorn
Jan 10, 2003·Clinical and Experimental Immunology·P MuratoriM Lenzi

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Citations

Aug 13, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B F F ChumpitaziC Drouet
Feb 9, 2012·The Kaohsiung Journal of Medical Sciences·Ming-Yen HsiehMing-Lung Yu
Mar 24, 2009·Journal of Viral Hepatitis·M J WilliamsUNKNOWN Trent HCV Group
Dec 24, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Martin-Walter Welker, Stefan Zeuzem
Jun 15, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Marwa KhairyMahassen Mabrouk
Apr 7, 2016·Journal of Immunoassay & Immunochemistry·Christine M Litwin, Steven R Binder
Sep 28, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sevİn KirdarNerİman Aydin
Jun 7, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Maíra Luciana MarconciniJanaína Luz Narciso-Schiavon
Apr 23, 2004·Genes and Immunity·L J Yee
Sep 17, 2018·Immunologic Research·Ana Beatriz da Silva SacerdoteEdmundo Pessoa Lopes
Apr 1, 2009·European Journal of Gastroenterology & Hepatology·Janaína L Narciso-SchiavonAntonio Eduardo B Silva
Jun 16, 2005·Current Opinion in Rheumatology·Manuel Ramos-Casals, Josep Font
Jun 21, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Luz Marina NavartaNelson Acosta-Rivero
Jun 9, 2015·World Journal of Hepatology·Janaína Luz Narciso-Schiavon, Leonardo de Lucca Schiavon
Jun 17, 2020·Immunologic Research·Ana Beatriz da Silva SacerdoteEdmundo Pessoa Lopes
May 5, 2018·Trends in Immunology·Juan Rivera-Correa, Ana Rodriguez
Aug 18, 2020·Autoimmunity Reviews·S John Calise, Edward K L Chan

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