Antinucleosome antibodies in primary antiphospholipid syndrome: a hint at systemic autoimmunity?

Journal of Autoimmunity
Laura AndreoliAngela Tincani

Abstract

Antinucleosome antibodies (anti-NCS) are reported to be highly sensitive and specific for systemic lupus erythematosus (SLE) and to correlate with disease activity. They may appear in early stages of the disease, in particular before anti-dsDNA antibodies, being a potential marker for identifying patients susceptible to SLE. Patients with primary antiphospholipid syndrome (PAPS) may develop full-blown SLE but there is no evidence for markers predictive for that. To evaluate whether anti-NCS may be predictors for full-blown or lupus like disease (LL) in a cohort of PAPS patients. A multicentric cohort of 105 PAPS patients was tested for IgG/IgM anti-NCS by using a home made assay with H1-stripped chromatin as antigen. Eighty-one out of 105 (77%) of the patients were positive for anti-NCS; medium-high titre results were present only in 49/105 (46%). Anti-NCS were more frequently detected in PAPS+LL, but no relationship with clinical/serological features was found, except for a weak correlation with anti-dsDNA antibodies. Two PAPS patients evolved into full-blown SLE during the follow-up and displayed high titre anti-NCS many years before. Our findings suggest that anti-NCS might be added to the mosaic of autoimmune phenomena char...Continue Reading

References

Sep 25, 1969·The New England Journal of Medicine·T PincusN Talal
Jul 1, 1994·The Journal of Clinical Investigation·R W BurlingameR L Rubin
Apr 1, 1993·The Journal of Clinical Investigation·R W BurlingameA N Theofilopoulos
Oct 3, 2006·Current Opinion in Immunology·Virginia PascualJacques Banchereau
Dec 2, 2006·Autoimmunity Reviews·Ricard CerveraJosep Font
Jan 31, 2007·Journal of Autoimmunity·Norbert Gleicher, David H Barad
Mar 17, 2007·Journal of Autoimmunity·Pierre Youinou
Oct 6, 2007·Clinical Reviews in Allergy & Immunology·Yehuda Shoenfeld
Dec 25, 2007·Journal of Autoimmunity·Aymeric BinardPierre Youinou
Dec 25, 2007·Journal of Autoimmunity·Olga Sánchez-PernauteSteffen Gay
Dec 29, 2007·Journal of Autoimmunity·C G M Kallenberg
Jan 8, 2008·Journal of Autoimmunity·Eric M JacobsonYaron Tomer
Jan 8, 2008·Journal of Autoimmunity·Yuko NakanishiM Eric Gershwin
Jan 15, 2008·Journal of Autoimmunity·Miri Blank, M Eric Gershwin
Jan 15, 2008·Journal of Autoimmunity·Michal AbrahamHoward L Weiner
Jan 15, 2008·Journal of Autoimmunity·Alexander B PoletaevM Eric Gershwin
Jan 15, 2008·Journal of Autoimmunity·Stefania RecalcatiGaetano Cairo
Jan 16, 2008·Journal of Autoimmunity·Ian R MackayNoel R Rose

❮ Previous
Next ❯

Citations

Dec 4, 2008·Clinical Reviews in Allergy & Immunology·Silvia BucciarelliRicard Cervera
May 1, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Renato Alberto SinicoAngela Tincani
May 8, 2014·Journal of Immunology Research·Sonal Mehra, Marvin J Fritzler
Jan 15, 2014·Clinical Rheumatology·Paula Vieira FreireJozélio Freire de Carvalho
Jul 9, 2008·Autoimmunity Reviews·José A Gómez-PuertaRicard Cervera
Jan 8, 2008·Journal of Autoimmunity·Eric M JacobsonYaron Tomer
Jan 8, 2008·Journal of Autoimmunity·Yuko NakanishiM Eric Gershwin
Jan 16, 2008·Journal of Autoimmunity·Ian R MackayNoel R Rose
Jan 15, 2008·Journal of Autoimmunity·Stefania RecalcatiGaetano Cairo
Jan 15, 2008·Journal of Autoimmunity·Michal AbrahamHoward L Weiner
Jan 15, 2008·Journal of Autoimmunity·Alexander B PoletaevM Eric Gershwin
Jan 15, 2008·Journal of Autoimmunity·Eric J BorenM Eric Gershwin
Jan 15, 2008·Journal of Autoimmunity·Miri Blank, M Eric Gershwin
Dec 29, 2007·Journal of Autoimmunity·C G M Kallenberg
Dec 25, 2007·Journal of Autoimmunity·Olga Sánchez-PernauteSteffen Gay
Dec 25, 2007·Journal of Autoimmunity·Aymeric BinardPierre Youinou
Aug 1, 2009·Arthritis and Rheumatism·Hong YinMarta E Alarcón-Riquelme
May 30, 2013·Autoimmunity·Laura AndreoliAngela Tincani
Mar 31, 2015·Journal of Immunology Research·Gabriella MoroniRenato Alberto Sinico
Oct 8, 2016·Arthritis Research & Therapy·Filomena PanzaPaola Migliorini
May 21, 2008·Lupus·S MullerP L Meroni
Jun 3, 2017·The Journal of Rheumatology·Mara TaraborelliAngela Tincani
Aug 20, 2016·Journal of Clinical Immunology·Marco CattaliniElisa Fazzi
Oct 9, 2009·Autoimmunity·Angela TincaniPier Luigi Meroni
Mar 13, 2019·Frontiers in Immunology·Pier Luigi Meroni, George C Tsokos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.