Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures

International Journal of Obesity : Journal of the International Association for the Study of Obesity
C M MackA A Young

Abstract

Exenatide (exendin-4) is an incretin mimetic currently marketed as an antidiabetic agent for patients with type 2 diabetes. In preclinical models, a reduction in body weight has also been shown in low-fat-fed, leptin receptor-deficient rodents. To more closely model the polygenic and environmental state of human obesity, we characterized the effect of exenatide on food intake and body weight in high-fat-fed, normal (those with an intact leptin signaling system) rodents. As glucagon-like peptide-1 receptor agonism has been found to elicit behaviors associated with visceral illness in rodents, we also examined the effect of peripheral exenatide on kaolin consumption and locomotor activity. High-fat-fed C57BL/6 mice and Sprague-Dawley rats were treated with exenatide (3, 10 and 30 microg/kg/day) for 4 weeks via subcutaneously implanted osmotic pumps. Food intake and body weight were assessed weekly. At 4 weeks, body composition and plasma metabolic profiles were measured. Kaolin consumption and locomotor activity were measured in fasted Sprague-Dawley rats following a single intraperitoneal injection of exenatide (0.1-10 microg/kg). Exenatide treatment in mice and rats dose-dependently decreased food intake and body weight; signif...Continue Reading

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B Thorens
Aug 1, 1993·Pharmacology, Biochemistry, and Behavior·N TakedaT Matsunaga
Jan 16, 1997·Nature·G van DijkI L Bernstein
Feb 1, 1997·The American Journal of Physiology·T E ThieleR J Seeley
Sep 29, 1998·Proceedings of the Society for Experimental Biology and Medicine·T WangC A Baile
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B K SmithD B West
Jan 11, 2001·Diabetologia·E Standl, O Schnell
Jun 19, 2001·American Journal of Physiology. Endocrinology and Metabolism·C M EdwardsS R Bloom
Jul 6, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A FlintA Astrup
May 29, 2003·Current Pharmaceutical Design·Philip J LarsenMads Tang-Christensen
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Orville G KoltermanAlain D Baron
Sep 30, 2003·Diabetes Care·Daniel J Drucker
Aug 28, 2004·Diabetes·Clyde GuidryCharles W Hardwick
Oct 27, 2004·Diabetes Care·John B BuseUNKNOWN Exenatide-113 Clinical Study Group
Jan 19, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M A Nauck
Feb 11, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Orville G KoltermanAlain D Baron
Nov 25, 2005·Diabetes·Catherine PihokerAke Lernmark

❮ Previous
Next ❯

Citations

Aug 1, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Seok Joon ShinCheol Whee Park
Apr 14, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H J Grill, M R Hayes
Feb 9, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N-C LiangT H Moran
Aug 21, 2007·Diabetes Technology & Therapeutics·Patric NelsonMark Fineman
Mar 27, 2009·Metabolic Syndrome and Related Disorders·Kevin D LaugeroDavid G Parkes
Jun 14, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerJames L Buescher
Dec 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C M MathesA C Spector
Jun 18, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas T BelloTimothy H Moran
Dec 17, 2008·Endocrinology·Diana L WilliamsMichael W Schwartz
Apr 18, 2009·Endocrinology·Timothy H Moran, Megan J Dailey
Sep 19, 2012·Endocrine Journal·Nanjing GuoDehong Cai
Jun 25, 2014·The Journal of Clinical Investigation·Zhongyi ChenSean S Davies
Apr 26, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joram D MulDarleen A Sandoval
Oct 14, 2008·Expert Opinion on Biological Therapy·Nicole C KestyDavid Maggs
Dec 25, 2015·Pharmacology, Biochemistry, and Behavior·Kimberly A Bernosky-SmithCaroline E Bass
Feb 7, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jee-Heon JeongYoungro Byun
Jan 5, 2011·Toxicon : Official Journal of the International Society on Toxinology·Brian L Furman
Mar 17, 2010·Physiology & Behavior·Matthew R HayesScott E Kanoski
Oct 20, 2009·Frontiers in Neuroendocrinology·Harvey J Grill
Dec 3, 2015·Canadian Journal of Physiology and Pharmacology·Vishal PatelMukul R Jain
Mar 29, 2012·British Journal of Clinical Pharmacology·Anne K McGavigan, Kevin G Murphy
Feb 11, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Jonathan W DayRichard D Dimarchi
Dec 15, 2012·The Journal of Comparative Neurology·Guibao GuJoseph S Heilig
Jan 27, 2011·British Journal of Pharmacology·Steven P VickersSharon C Cheetham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.