Antiobesity Effect of Tricin, a Methylated Cereal Flavone, in High-Fat-Diet-Induced Obese Mice

Journal of Agricultural and Food Chemistry
Dabeen Lee, Jee-Young Imm

Abstract

The antiobesity potential of tricin, a methylated cereal flavonoid, was examined using a high-fat-diet-induced obese mice model. The body weight ( P < 0.01) and body fat mass ( P < 0.05) were significantly decreased in the high-dose tricin supplementation group (TH: 200 mg/kg diet) in comparison to the high fat diet control group (CON) after a 12-week feeding trial. The serum (60.9 ± 2.09 mg/dL) and hepatic triglyceride levels (45.3 ± 4.42 nmol/mg protein) in the TH group were significantly decreased in comparison to the CON group (78.3 ± 5.09 mg/dL, 76.3 ± 8.10 nmol/mg protein), respectively. This antiobesity effect was attributed to a decrease in the expression of lipogenic markers crucial for fat synthesis in the liver (fatty acid synthase, stearoyl-CoA desaturase 1, elongation of long-chain fatty acids family member 6, glycerol-3-phosphate acyltransferase, and diglyceride acyltransferase) and suppressed expression of transcription factors associated with adipocyte differentiation (peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding protein α). These lipid-lowering effects are mediated by the activation of adenosine 5'-monophosphate-activated protein kinase.

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Citations

May 29, 2020·Critical Reviews in Food Science and Nutrition·Ao ShangHua-Bin Li
Oct 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Xiao LiuWei Wang
Apr 23, 2019·Journal of the American College of Nutrition·Jin JiBarry Kitchen
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Grace Gar-Lee YueClara Bik-San Lau
Apr 22, 2020·Natural Products and Bioprospecting·Rong-Fang MuWen-Yong Xiong
Feb 20, 2021·Journal of the American College of Nutrition·Nathália Ferreira LousekClayson Moura Gomes

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