Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice

Evidence-based Complementary and Alternative Medicine : ECAM
Yun-Ho HwangSung-Tae Yee

Abstract

Protective effect of new oriental medicine (Kyungokgo mixed with water extract of Hovenia dulcis, KOGHD) was assessed on the bone loss induced mice by ovariectomy. In the in vivo experiments, antiosteoporosis effect of KOGHD was investigated using ovariectomized osteoporosis mice model. After 6 weeks of treatment, the mice were euthanized, and the effect of Kyungokgo (KOG) and KOGHD on body weight, spleen weigh, thymus weight, uterine weight, serum biochemical indicators, bone weight and length, immune cell population, bone morphometric parameters, and histological stains was observed. Our results showed that KOGHD prevented the deterioration of trabecular microarchitecture caused by ovariectomy, which were accompanied by the lower levels of bone turnover markers and immune cell population as evidenced by the inhibition of RANKL-mediated osteoclast differentiation without cytotoxic effect on bone marrow derived macrophages (BMMs). Therefore, these results suggest that the Hovenia dulcis (HD) supplementation in the KOG may also prevent and treat bone loss.

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·I MacIntyreJ R Vane
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T Takano-Yamamoto, G A Rodan
Jan 1, 1997·Annual Review of Nutrition·M S Kurzer, X Xu
Mar 12, 1998·Endocrine Reviews·C OhlssonM C Slootweg
Nov 22, 2000·The Journal of Clinical Investigation·S CenciR Pacifici
Aug 24, 2005·Archives of Pharmacal Research·Gao LiHyeong-Kyu Lee
Jul 13, 2006·Annals of the New York Academy of Sciences·M Neale Weitzmann, Roberto Pacifici
Sep 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francesco GrassiRoberto Pacifici
Oct 9, 2007·International Immunopharmacology·Cheol Kyu ParkHong-Hee Kim
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Laura E WrightPatricia B Hoyer
May 30, 2008·Life Sciences·Jeong A ParkSun Yeou Kim
Mar 18, 2010·The Journal of Nutritional Biochemistry·Tae-Ho KimShin-Yoon Kim
Oct 12, 2011·Phytotherapy Research : PTR·Byung-Su AhnSung-Ho Kim
Jul 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mingchun WangXiaoxiong Zeng
Dec 12, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Liming XueLuping Qin
Jun 14, 2013·Clinical & Developmental Immunology·Maria Felicia FaienzaLuciano Cavallo
Oct 22, 2013·Bone·Babita BalakrishnanShubhada V Chiplunkar
Nov 16, 2013·Journal of Ginseng Research·Jin-Hee LeeSung-Ho Kim

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Citations

Oct 18, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Yun-Ho HwangSung-Tae Yee
Aug 30, 2018·International Journal of Molecular Sciences·Su-Jin KimSung-Tae Yee

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Methods Mentioned

BETA
hormone replacement therapy
ELISA
FACS
flow cytometry

Software Mentioned

CTAn analyser

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