PMID: 11907391Mar 22, 2002Paper

Antioxidant actions and early ultrastructural findings of thiopental and propofol in experimental spinal cord injury

Journal of Neurosurgical Anesthesiology
E KaptanogluYamac Taskin

Abstract

Thiopental and propofol are effective antioxidant agents. The current study was undertaken to examine the neuroprotective effects of a single intraperitoneal dose of thiopental and propofol. Effects of the drugs were evaluated by lipid peroxidation and ultrastructural findings. Fifty male Wistar rats were divided into five groups. Group 1 was the control group. Rats underwent laminectomy only, and nontraumatized spinal cord samples were obtained 1 hour after surgical intervention. All other rats sustained a 50-g/cm contusion injury by the weight drop technique. Group 2 rats underwent spinal cord injury alone, group 3 rats received 1 mL intralipid solution intraperitoneally immediately after trauma as the vehicle group, group 4 rats received a 15-mg/kg single dose of thiopental, and group 5 rats received a 40-mg/kg single dose of propofol intraperitoneally following the trauma. Samples from groups 2, 3, 4, and 5 were obtained 1 hour after injury. Lipid peroxidation was determined by measuring the concentration of malondialdehyde in the spinal cord tissue. The ultrastructure of the spinal cord was determined by electron microscopy. The contusion injury was associated with a rise in lipid peroxidation. Compared with the trauma gro...Continue Reading

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Citations

May 9, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ferhat HarmanErkan Kaptanoglu
Jun 1, 2011·Pediatric Surgery International·Ersoy TaşkaraAhmet Can Senel
Mar 23, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Edward D Hall
May 24, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Erkan KaptanogluYamac Taskin
Feb 18, 2014·The Spine Journal : Official Journal of the North American Spine Society·Onur YamanCüneyt Temiz
Feb 2, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sanser GulBektas Acikgoz
May 19, 2005·Pharmacotherapy·Paul E Marik
Sep 27, 2007·CNS Drug Reviews·Chiara AdembriDomenico E Pellegrini-Giampietro
Dec 21, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Erkan YildirimUnal Sakinci
Nov 3, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Erkan KaptanogluEtem Beskonakli
Aug 21, 2007·Redox Report : Communications in Free Radical Research·Samar BasuClaus G Krenn
May 20, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thiruchenduran MohanaSivasithamparam Niranjali Devaraj
Oct 20, 2020·Arhiv za higijenu rada i toksikologiju·Sandra Alavuk KundovićKsenija Črnjar

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