Antioxidant activities and lipid lowering effects of isoflavone in male rabbits

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Mokhtar I YousefHoda H Baghdadi

Abstract

Dietary flavonoids appear to play a role in the prevention of a number of chronic diseases such as cancer and cardiovascular disease and the soy isoflavones have been the focus of particular. Consumption of soy isoflavones may reduce the risk of cardiovascular disease both through reduction in serum lipids and by the antioxidant properties. We have therefore investigate the effects of either 2.5 or 5 mg/kg B.W. doses of isoflavones on the levels of free radicals, lipids and lipoproteins in male New Zealand White rabbits. Animals were orally given 2.5 or 5 mg/kg B.W. doses of isoflavones. The tested doses were given to rabbits every other day for 13 weeks. Treatment with isoflavones caused significant (P<0.05) decrease in the concentrations of free radicals in plasma by 33% and 35%, liver by 18% and 27%, brain by 12% and 33%, testes by 40% and 21%, and kidney by 38% and 20% for 2.5 or 5 mg/kg B.W. doses, respectively, as compared to the control. On the other hand, the activity of glutathione S-transferase (GST) did not change in treated animals as compared to control. Also, results showed that isoflavones caused a significant decrease (P<0.05) in the levels of plasma total lipids (TL) by 16% and 19%, total cholesterol by 20% and...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V W BowryR Stocker
Jan 1, 1989·Reproductive Toxicology·R S Kaldas, C L Hughes
May 1, 1995·Journal of Animal Science·N R Adams
Aug 1, 1996·Current Opinion in Lipidology·S M Potter
Jun 1, 1997·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·N A HelsbyJ K Chipman
Jan 1, 1997·Annual Review of Nutrition·M S Kurzer, X Xu
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·M J TikkanenH Adlercreutz
Dec 16, 1998·The American Journal of Clinical Nutrition·M S AnthonyJ K Williams
Mar 4, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·G S DeviP P Reddy
Mar 22, 2002·European Journal of Nutrition·M Q RenJ Chen
Apr 12, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·J SierensJ V Woodside
Apr 29, 2003·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·F M el-DemerdashK S Al-Salhen
Jul 25, 2003·European Journal of Clinical Nutrition·R M Weggemans, E A Trautwein
Sep 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·D WATSON

❮ Previous
Next ❯

Citations

Jun 7, 2005·Toxicology and Applied Pharmacology·Hsiu-Mei ChiangPei-Dawn Lee Chao
Sep 20, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Stalin SelvarajUma Maheswari Krishnan
Feb 16, 2010·Nutrition and Cancer·Kazim SahinOmer Kucuk
Aug 5, 2011·The Journal of Nutritional Biochemistry·Hsin-Yi YangJiun-Rong Chen
Sep 21, 2010·Metabolism: Clinical and Experimental·Katarzyna SzkudelskaTomasz Szkudelski
Jun 26, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Katarzyna Szkudelska, Leszek Nogowski
May 25, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Tsui Yao Chen, Bonnie Sun Pan
Apr 23, 2013·Journal of the Science of Food and Agriculture·Asghar A Kamboh, Wei-Yun Zhu
Nov 23, 2012·Environmental Toxicology·Ayman El-meghawry El-KenawyMaha Hasan Daghestani
Oct 7, 2010·Journal of Diabetes·Sumiyabanu Mohamed SalihAnuradha Carani Venkatraman
Apr 5, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Hoon JangChang-Hee Han
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Al-Sayeda A NewairyMokhtar I Yousef
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mokhtar I Yousef, Afrah F Salama
Jul 31, 2016·Chinese Journal of Natural Medicines·Jing-Jing TangRong Hu
Jul 24, 2008·Metabolic Brain Disease·Siomara C MonteiroAngela T S Wyse
Jul 5, 2017·Experimental and Therapeutic Medicine·Bin Wang, Cunbing Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
M J TikkanenH Adlercreutz
Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Mokhtar I YousefK S Al-Salhen
Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Fatma M El-DemerdashK S Al-Salhen
© 2022 Meta ULC. All rights reserved