PMID: 22362141Mar 1, 2012Paper

Antioxidant activities of Perilla frutescens against low-density lipoprotein oxidation in vitro and in human subjects

Journal of Oleo Science
Emi SaitaKazuo Kondo

Abstract

Perilla (Perilla frutescens (L.) Britt.) is a popular food as well as a traditional medicine in Japan, China, and other Asian countries. The aim of this study was to investigate the inhibitory effects of perilla on low-density lipoprotein (LDL) oxidation in vitro and in human subjects. We compared the antioxidant activities of red perilla and green perilla. Both green and red perilla had high 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities and were abundant in polyphenol compounds. In addition, the radical scavenging activity and polyphenol content of red perilla were higher than those of green perilla. Perilla dramatically inhibited azo-radical-induced LDL oxidation and endothelial-cell-mediated LDL oxidation in vitro. Moreover, red perilla significantly increased mRNA and protein expression levels of antioxidant enzymes in endothelial cells. We further examined the antioxidant effects against LDL in human subjects after the consumption of perilla extracts. After oral intake of red perilla, the subjects' LDL oxidation lag times were significantly longer than those before the intake. Furthermore, lipid peroxide formation and the electrophoretic mobility of LDL decreased markedly. These results suggested that perilla...Continue Reading

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Citations

Feb 14, 2013·European Journal of Clinical Nutrition·Y KishimotoK Kondo
Nov 10, 2015·Chemistry and Physics of Lipids·Toshimi KidoShinji Yokoyama
Dec 19, 2013·Oxidative Medicine and Cellular Longevity·Irakli ChkhikvishviliVictor Rodov
Feb 13, 2015·International Journal of Molecular Medicine·Sin-Hye ParkYoung-Hee Kang
Jun 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sae-Kwang KuJong-Sup Bae
Aug 19, 2015·Clinical Medicine Insights. Cardiology·Emi SaitaYukihiko Momiyama
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michio HashimotoOsamu Shido
Jan 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiwa M Ahmed
May 22, 2018·Current Atherosclerosis Reports·Paola Toledo-Ibelles, Jaime Mas-Oliva

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