Antioxidant Activity and Anti-wrinkle Effects of Aceriphyllum rossii Leaf Ethanol Extract

Toxicological Research
Bi Gyeon HaYoung Chul Kim

Abstract

We evaluated the antioxidant activity and anti-wrinkle effects of Aceriphyllum rossii leaf ethanol extract (ARLEE) in vitro using human dermal fibroblasts. The total polyphenol and flavonoid contents of ARLEE were 578.6 and 206.3 mg/g, respectively. At a concentration of 250 μg/mL, the electron-donating ability of ARLEE was 87.1%. In comparison with the vehicle, ARLEE treatment at 100 μg/mL significantly increased type I procollagen synthesis (p < 0.01) by 50.7%. In vitro ARLEE treatment (10 mg/mL) inhibited collagenase and elastase activity by 97.1% and 99.2%, respectively. Compared with the control, ascorbic acid treatment at 100 μg/mL significantly decreased matrix metalloproteinase (MMP)-1 protein expression (p < 0.01) by 37.0%. ARLEE treatment at 50 μg/mL significantly decreased MMP-1 protein expression (p < 0.01) by 46.1%. Ascorbic acid and ARLEE treatments at 100 μg/mL significantly decreased MMP-1 mRNA expression (p < 0.01) by 26.1% and 36.1%, respectively. From these results, we conclude that ARLEE has excellent antioxidant activity and even better anti-wrinkle effects than ascorbic acid in human dermal fibroblasts. These results suggest that ARLEE could be used in functional cosmetics for the prevention or alleviation...Continue Reading

References

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Citations

Nov 11, 2016·Biomolecules & Therapeutics·Susara Ruwan Kumara Madduma HewageJin Won Hyun
Jan 19, 2017·International Journal of Molecular Medicine·Quynh Lien PhamKyu-Bong Kim
May 16, 2017·Toxicological Research·Min Ah ParkYoung Chul Kim
May 14, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Katarzyna JakimiukMichał Tomczyk

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Methods Mentioned

BETA
ELISA
Protein Assay
electrophoresis
PCR

Software Mentioned

SPSS
Image J

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