Antioxidant Activity and Hepatoprotective Potential of Quercetin 7-Rhamnoside In Vitro and In Vivo

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Zhi-Qiang HuangPei-Bo Li

Abstract

Hypericum japonicum is traditionally used as a folk medicine to treat cholestasis and hepatitis. Quercetin 7-rhamnoside (Q7R) is one of the main flavonoid components of Hypericum japonicum and has been rarely studied. The aim of the present study was to evaluate the antioxidant activity and hepatoprotective potential of Q7R. In the in vitro experiments, DPPH, ABTS and ferric reducing antioxidant power (FRAP) assays were first performed to assess the antioxidant properties of Q7R, and then a H₂O₂-induced oxidative damage cellular model was used to determine the cytoprotective and antioxidant properties of Q7R in human liver L-02 cells. In the in vivo experiment, the hepatoprotective activity of Q7R was evaluated by carbon tetrachloride (CCl₄)-induced liver damage model in mice. The results of the three in vitro assays (DPPH, ABTS and FRAP) demonstrated that Q7R significantly exhibited antioxidant activity. The cell experiment results showed that Q7R possessed cytoprotective and antioxidant effects on H₂O₂-treated L-02 cells. In the in vivo experiments, Q7R suppressed the up-regulation of serum activities of ALT, AST, LDH and triglyceride (TG) levels with dose-dependency. Q7R down-regulated the production of MDA and increased the...Continue Reading

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Citations

Aug 29, 2020·Oxidative Medicine and Cellular Longevity·Lúcio Ricardo Leite DinizDamião Pergentino de Sousa
Jun 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samuel Odeyemi, John Dewar
Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xinyu ZhaoDaozong Xia
Jun 4, 2021·Inflammation·Ana Carolina de Figueiredo CostaDelane Viana Gondim

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SPSS

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