PMID: 9538941Apr 16, 1998Paper

Antioxidant activity in alveolar epithelial type 2 cells of rats during the development of bleomycin injury

Cell Biology and Toxicology
H KaramB Housset

Abstract

Bleomycin (BLM) induces lung inflammation and subsequent fibrosis in human and in animal models. Alveolar epithelial type 2 cells (T2 cells) are known to play a crucial role in the repair process after BLM injury. We hypothesized that resistance of T2 cells to BLM-damage was associated with an increase in their antioxidant system activity. We developed an animal model of lung lesions preceding fibrosis, using daily intraperitoneal administration of BLM (1.5 mg/day over 7 and 14 days). We observed a body weight stabilization in BLM-treated rats from the third day. After 14 days of BLM treatment, the number of cells recovered by bronchoalveolar lavage was significantly increased (p < 0.05), with a dramatic increase (p < 0.01) in the percentage of neutrophils associated with a decrease in macrophage percentage (p < 0.01) No evidence of fibrosis was seen by microscopic studies at this time. However, T2 cells in 14-day-treated rats were swollen with enlarged lamellar inclusion bodies. Biochemical study of freshly isolated T2 cells displayed a significant decrease of lactate dehydrogenase (LDH) released by these cells when isolated from 14-day-treated rats as compared with 7-day. By contrast, BLM induced an increase in superoxide dis...Continue Reading

Citations

Feb 14, 2002·Journal of Pineal Research·Seyfullah O ArslanAli Coskun
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Regina M DayBarry L Fanburg
Nov 25, 2005·Histochemistry and Cell Biology·Simona InghilleriCarla Fenoglio
Dec 9, 2008·American Journal of Respiratory and Critical Care Medicine·Paul F MercerRachel C Chambers
Jul 3, 2015·Molecular Medicine Reports·Yue GuJia-Ning Yin
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Russell P BowlerJames D Crapo
Dec 7, 2002·American Journal of Respiratory and Critical Care Medicine·Annie PardoMoisés Selman
Aug 16, 2005·Journal of Pineal Research·Tiziana GenoveseSalvatore Cuzzocrea
Jan 13, 2005·The Journal of Pharmacology and Experimental Therapeutics·Tiziana GenoveseSalvatore Cuzzocrea

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